A Study Evaluating the Overall Pain Relief and Safety of Intravenous (IV) CR845 in Patients Undergoing Abdominal Surgery

Patients will be admitted to the surgical center on the day of their abdominal surgery (Day
1, unless admission the night before is required). All patients will be seen by the study
staff to confirm eligibility, review study procedures, and conduct all pre-surgical
assessments required for randomization.

Qualified patients will be randomized into 1 of 3 treatment groups, corresponding to 1 of 2
dose levels of intravenous (IV) CR845 (0.5 or 1 mcg/kg) or matched placebo, respectively.

Study drug will be administered every 6 hours during the 24-hour post-operative treatment
period following these initial 2 drug administrations:

- Pre-Operative dose: Within one hour prior to anesthetic induction for surgery. This dose
will be a 2X loading dose.

- Baseline post-operative dose: within 30-minutes of being considered stable in the
Post-Anesthesia Care Unit (PACU)

Subsequent dosing will be administered at 6, 12 and 18 hours.

During the Treatment and Observation Period, pain intensity scores will be obtained at
specified time points and episodes of nausea or vomiting will be recorded. Upon request,
patients may be provided with analgesic or anti-nausea rescue medication (restricted to
morphine (if tolerated), and ondansetron, respectively) at any time after the Baseline dose
of study drug is administered.

Blood sampling and safety assessments will be conducted during this period as well.

Patients will remain in the hospital until Day 3 (48-hours after surgery) at which point they
will be evaluated for discharge. A follow-up medical evaluation will be scheduled within 7 -
10 days post-surgery.

Inclusion Criteria:

- A patient will be eligible for study participation if the subject meets the following
criteria:

1. Voluntarily provide written informed consent to participate in the study prior to any
study procedures.

2. Able to speak, read, and communicate clearly in English or Spanish; able to read and
understand the study procedures.

3. Male or female between 21 and older at the time of Screening.

4. Scheduled for abdominal surgery (hysterectomy; prostatectomy; hemi-colectomy
(including partial bowel resections) or ventral hernia repair) with no collateral
procedures.

5. Patient is categorized as American Society of Anesthesiologists (ASA) risk class of I,
II or III.

6. Has a body mass index (BMI) within 18.0-40.0 kg/m2 and weight between 50 kg and 112
kg, inclusive.

7. For women of childbearing potential- has a negative result on serum pregnancy testing
at Screening and urine pregnancy test at Admission and does not currently breast feed,
or is planning to do so within 30 days of receiving the last dose of study drug.

8. If female, the patient must be:

- Of childbearing potential and practicing an acceptable form of birth control
(defined as the use of an intrauterine device; a barrier method with spermicide;
condoms, any form of hormonal contraceptives; or abstinence from sexual
intercourse) for 3 days following the last dose of study drug.

- Of non-childbearing potential defined as surgically or biologically sterile
(hysterectomy, bilateral oophorectomy, bilateral tubal ligation or postmenopausal
for at least 1 year).

9. If male, the patient must be surgically or biologically sterile. If not sterile, the
patient must agree to use an acceptable form of birth control with heterosexual
partner (as described in inclusion criteria #8a) or abstain from sexual relations for
3 days following the last dose of study drug.

10. Is free of other physical, mental, or medical conditions, which, in the opinion of the
Investigator, would make study participation inadvisable.

11. Following surgery, the patient will be eligible for the second dose of study drug.

Exclusion Criteria:

A patient will be excluded from the study if any of the following criteria are met:

1. Has a serum sodium level > 143 mmol/L at Screening.

2. Has a serum sodium level < 136 mmol/L at Screening.

3. Patient is unwilling or unable to comply with the study procedures and assessments
until the end of the 48-hour treatment and observation period.

4. Has moderate to severe obstructive sleep apnea, which, in the opinion of the
Investigator is not being adequately treated (i.e., Nasal/Facial C-PAP), and will pose
an unacceptable risk.

5. Has known allergies or hypersensitivity to drugs that may be used during the study,
including those used during the surgical procedure and in the post-operative period
[e.g., inhaled anesthetics (such as sevoflurane), midazolam, opioids (such as fentanyl
and morphine sulfate), propofol or other sedatives, local anesthetics, antiemetics
(such as ondansetron) non- steroidal anti-inflammatory drugs (such as ketorolac) or
acetaminophen].

6. Uses antipsychotics, antiepileptics, sedatives, hypnotics, or antianxiety agents,
selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants with a dose
change < 30 days prior to surgery.

7. Has a history or current diagnosis of substance dependence (except caffeine or
nicotine) or alcohol abuse, according to the criteria of Diagnostic and Statistical
Manual of Mental Disorders, Fifth Edition (DSM-5).

8. Has a positive urine drug screen for drugs of abuse at Screening.

9. Is unwilling to abstain from alcohol consumption for a period beginning 24 hours prior
to Admission until the time of Discharge from the hospital.

10. Suffers from chronic dizziness, vestibular disorders, or has experienced severe
continuous diarrhea, retching, vomiting, or moderate or severe nausea and/or dizziness
for any reason within 72 hours prior to Admission.

11. Has been diagnosed with a condition of hyperhidrosis (excessive sweating) or primary
hypodipsia (abnormally diminished thirst).

12. Has donated or had significant loss of whole blood (240 mL or more) within 30 days or
plasma within 14 days prior to Admission.

13. Has a history (within 6 months) of clinically meaningful orthostatic changes in vital
signs - OR - a decrease in systolic blood pressure by > 20 mm Hg or a decrease in
diastolic blood pressure by 10 mm Hg together with an increase in heart rate of > 30
beats per minute when transitioning from supine to standing measurements at the time
of Screening.

14. Hasmedicalconditions(e.g.,cardiovascular,pulmonary,hepatic,renal, hematologic,
gastrointestinal, endocrine (adrenal hyperplasia), immunologic, dermatologic,
neurologic, oncologic or psychiatric condition) or a significant laboratory
abnormality that, in the Investigator's opinion, would jeopardize the safety of the
patient or is likely to confound the study measurements.

15. Has congestive heart failure.

16. Has taken any diuretic medications within 2-weeks prior to the scheduled surgery.

17. Has an oxygen saturation < 92% on room air at Screening or Admission.

18. Has impaired renal function indicated by serum creatinine greater than 2 times the
reference upper limit of normal (ULN).

19. Has a serum alanine aminotransferase (ALT) or aspartate aminotransferase AST) greater
than 2.5 times the reference upper limit of normal (ULN), or total bilirubin greater
than 2 times the ULN at Screening.

20. Has, in the opinion of the Investigator, any clinical signs of dehydration or
hypovolemia (e.g., symptomatic hypotension) or associated laboratory abnormalities,
e.g., elevated hematocrit, elevated blood urea nitrogen (BUN) >1.5 x the reference ULN
at Screening.

21. Has taken opioid analgesics for more than 10 consecutive days for any reason within
the past 3 months prior to Screening.

22. Has taken opioid or non-opioid pain medication (e.g., NSAIDs such as naproxen,
cyclooxygenase-2 inhibitors) within the 12 hours prior to surgery.

23. Has received another investigational drug within 30 days prior to Admission or has
planned to participate in another clinical trial while enrolled in this study.