Transcranial Treatments in Eating Disorders



Status:Recruiting
Conditions:Psychiatric, Psychiatric, Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 65
Updated:4/21/2016
Start Date:August 2015
Contact:Guido K. Frank, MD
Email:guido.frank@ucdenver.edu
Phone:7207771909

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Novel Transcranial Treatments to Modulate Taste Reward and Body Perception Pathways in Eating Disorders

The primary aim of this study is to study how Repetitive Transcranial Magnetic Stimulation
(rTMS) tailored to specific anorexia nervosa (AN) or bulimia nervosa (BN) brain activation
alterations will promote recovery and to study how inhibitory tDCS (Transcranial Direct
Current Stimulation) will reduce symptoms of body image distortion in a second sample of AN
and BN groups.


Inclusion Criteria:

- Anorexia Nervosa subjects:

- Meets DSM-5 criteria for anorexia nervosa (AN) either binge-eating/purging type or
restricting-type:

- Intense fear of gaining weight or becoming fat, even though underweight.

- The ability to undergo an MRI, fMRI or other similar procedure requiring spending
time in an enclosed space

- Bulimia Nervosa subjects:

- Meet DSM-5 criteria for bulimia nervosa (BN):

- Self-induced vomiting; misuse of laxatives, diuretics, enemas, medication, fasting,
excessive exercise.

Exclusion Criteria:

- Electrolyte, blood count or kidney or liver function abnormalities.

- No symptoms of alcohol or other substance abuse or dependence in the past 3 months,

- No previous or current organic brain syndromes, dementia, psychotic disorders,
somatization disorders, or conversion disorder, head trauma, indication of mental
retardation or pervasive developmental disorder.

- No antipsychotics, tricyclic antidepressants or Wellbutrin or other medication that
may lower the seizure threshold.

- Claustrophobia.
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Aurora, Colorado 80045
Phone: 720-777-1909
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