Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN
| Status: | Completed |
|---|---|
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 1/12/2019 |
| Start Date: | March 24, 2014 |
| End Date: | November 6, 2018 |
The NeuroVISION Study will characterize the incidence, impact, and risk factors of covert
stroke in adults undergoing noncardiac surgery. We will determine the incidence of acute
covert stroke using an MRI study of the brain in the days following noncardiac surgery. We
will characterize the epidemiology and the impact of covert stroke in patients undergoing
noncardiac surgery, and its association with cerebral deoxygenation.
stroke in adults undergoing noncardiac surgery. We will determine the incidence of acute
covert stroke using an MRI study of the brain in the days following noncardiac surgery. We
will characterize the epidemiology and the impact of covert stroke in patients undergoing
noncardiac surgery, and its association with cerebral deoxygenation.
At the University of Wisconsin a planned sub study of NeuroVISION is being conducted aiming
to enroll 100 patients with additional cognitive testing, MRI sequences and a preoperative
MRI scan.
At Hamilton Juravinski Hospital, Hamilton General Hospital, Auckland City Hospital and Prince
of Wales Hospital a planned sub study of NeuroVISION (PAFS - Perioperative Atrial
Fibrillation and Postoperative Stroke) is being conducted aiming to enroll 400 participants.
The purpose of this sub-study is to determine the prevalence of AF(Atrial Fibrillation)
before surgery (i.e. "background" AF), as well of the incidence of AF after surgery using the
Icentia CardioSTAT "patch-like" single lead heart rhythm monitor.
to enroll 100 patients with additional cognitive testing, MRI sequences and a preoperative
MRI scan.
At Hamilton Juravinski Hospital, Hamilton General Hospital, Auckland City Hospital and Prince
of Wales Hospital a planned sub study of NeuroVISION (PAFS - Perioperative Atrial
Fibrillation and Postoperative Stroke) is being conducted aiming to enroll 400 participants.
The purpose of this sub-study is to determine the prevalence of AF(Atrial Fibrillation)
before surgery (i.e. "background" AF), as well of the incidence of AF after surgery using the
Icentia CardioSTAT "patch-like" single lead heart rhythm monitor.
Inclusion Criteria:
- Age ≥65 years old
- An anticipated hospital stay of at least 2 days after elective noncardiac surgery that
occurs under general or neuraxial anesthesia
- Written informed consent for potential participation prior to noncardiac surgery
Exclusion Criteria:
- Contraindication to MRI (e.g. implanted devices not safe for MRI studies,
claustrophobia)
- Unable or unwilling to attend the follow-up appointments
- Documented history of dementia
- Residing in a nursing home
- Undergoing carotid artery surgery or intracranial surgery
- Unable to complete neurocognitive testing due to language, vision or hearing
impairment
- Unable to communicate with the research staff due to language barriers
- Patients who do not undergo their research MRI study after surgery
- Patients who do not complete a baseline MoCA questionnaire
- Patients who suffer an acute overt clinical stroke after the index surgery, but before
their research MR study
- Previously enrolled in the NeuroVISION Study.
We found this trial at
2
sites
Madison, Wisconsin 53792
(608) 263-2400
Principal Investigator: Robert Sanders, MD
Phone: 608-263-0575
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Vancouver, British Columbia
Principal Investigator: Carl Brown, MD
Phone: 604-806-9604
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