Evaluating Muscle Weakness Improvement With Lorcaserin in ICU

Inclusion Criteria:

1. Age ≥18 years old

2. Sepsis [ ≥2 Systemic Inflammatory Response Syndrome (SIRS) Criteria AND known or
suspected infection]

3. Muscle weakness [Medical Research Council sum score <48/60 or handgrip strength <11 kg
in men and <7 kg in women]

4. Obey Commands [Score for DeJonghe Awakening Score of ≥3/5]

Exclusion Criteria:

1. Severe renal insufficiency [Creatinine Clearance <30 mL/min - or receiving dialysis]

2. Acute infectious or auto-immune hepatitis, acute liver failure or a history of
cirrhosis without liver transplant

3. History of psychosis

4. Bradycardia, or 2nd or 3rd degree AV block without pacemaker

5. History of valvular heart disease without valve replacement

6. History of priapism

7. Pre-existing cognitive impairment

8. Receiving drugs with serotonergic effects and/or CYP2D6 substrates which cannot be
substituted stopped or titrated.

9. Receiving Sulfonylurea medication at the time of the study

10. Prior neuromuscular or central nervous system disease, including pre-existing
neuropathy

11. Inability to perform study's muscle strength assessments based on patient's baseline
status prior to hospital admission

12. Unable to receive, or unlikely to absorb study drug (e.g. bowel obstruction, ischemia,
or infarction; short gut syndrome)

13. Body mass index >40

14. Patient not expected to survive >4 days

15. Pregnancy or lactation

16. Allergy to lorcaserin or lorcaserin taken in the prior 7 days

17. Enrolled in another interventional drug or physical rehabilitation trial

18. Physician declines for patient to be enrolled

19. Patient or proxy declines consent

20. Unable to reach proxy for consent

21. Non-English speaking