Intervention for Pre-Frailty and Frailty in Thoracic Surgery Patients



Status:Recruiting
Healthy:No
Age Range:60 - Any
Updated:5/12/2016
Start Date:July 2015
End Date:February 2017
Contact:Paul Pachwicewicz
Email:ppachwicewicz@surgery.bsd.uchcago.edu
Phone:773 702-9113

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Frailty has been associated with poor acute and long-term outcomes after major surgery. We
recently determined that nearly 70% of patients undergoing major thoracic surgery are
pre-frail or frail. We are interested in assessing whether a strength training intervention
for frail or pre-frail patients has an impact on surgical decision making and on surgical
outcomes.


Inclusion Criteria: • Age ≥60 years, • Qualified to consent for participation in a
research study, •Thoracic disease that may require major surgery (major anatomic lung
resection, esophagectomy, repair of giant paraesophageal hernia, chest wall resection,
extended pleurectomy/decortication, thymectomy or major surgery for other mediastinal
process),• No obvious contraindications to surgery (end-stage heart disease, end-stage
lung disease, severe dementia, other specific comorbidity that would prevent surgery), •
Ability to participate in physical therapy and an independent exercise program for frailty
mitigation, •No need for induction chemotherapy or radiation therapy, • Recent evaluation
including computed tomography of the chest or chest/abdomen.

Exclusion Criteria:• Age <60 years, •Unable to provide informed consent, • No indication
for major thoracic surgery, •Obvious contraindication to major thoracic surgery (end-stage
heart disease, end-stage lung disease, severe dementia, other specific comorbidity that
would preclude surgery),• Inability to participate in physical therapy and/or an
independent home exercise for frailty mitigation, •Need for induction chemotherapy or
radiation therapy
We found this trial at
1
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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