Effectiveness of Home-based Electronic Cognitive Therapy in Alzheimer's Disease

In the current study, the investigators are examining the use of a mobile electronic
application used to deliver cognitive rehabilitation tasks to patients with mild cognitive
impairment due to Alzheimer's disease, and patients with mild Alzheimer's disease. An
estimated 100 patients will be enrolled into the study (~50 patients with mild cognitive
impairment, ~50 patients with Alzheimer's disease).

Participants will either receive memory tasks designed to help stabilize or improve memory
(Intervention Group) or a set of word or math puzzles (Control Group). Participants will
complete memory tasks or puzzles for a six month period. The investigators will conduct pre-
and post- neuropsychological testing to assess changes in cognitive status (e.g., memory,
language, executive functioning) in the intervention group. Neuropsychological tests
assessing changes to cognition will be completed prior to participant assignment to the
Intervention or Control Group. Both groups will then be assessed again using
neuropsychological tests. The investigators will also assess changes in performance on
cognitive rehabilitation tests over the six month period to determine the efficacy of these
tasks.

Inclusion Criteria:

- A diagnosis of mild cognitive impairment due to Alzheimer's disease (MCI due to AD) by
the patient's referring clinician per recent National Institutes of Aging-Alzheimer's
Association criteria (Albert et al., 2011).

- A diagnosis of mild Alzheimer's disease by the patient's referring clinician per
recent National Institutes of Aging-Alzheimer's Association criteria (McKhann et al.,
2011).

- 50-90 years of age.

Exclusion Criteria:

- Younger than the age of 50 or older than the age of 90.

- Any self-reported history of substance abuse or alcohol abuse.

- Any self-reported history of prior head trauma (e.g., stroke, traumatic brain injury)

- Any prior self-reported history of significant depression or other mood disorder.