Vaginal Cleansing Before Cesarean Delivery to Reduce Infection
| Status: | Recruiting |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 5/12/2018 |
| Start Date: | August 2015 |
| End Date: | December 2019 |
| Contact: | Antonina I Frolova, MD |
| Email: | frolovaa@wudosis.wustl.edu |
| Phone: | 314-362-7300 |
Vaginal Cleansing Before Cesarean Delivery to Reduce Infection: A Randomized Trial
The purpose of this study is to test the hypothesis that vaginal cleansing with
povidone-iodine solution immediately prior to cesarean delivery reduces postcesarean
infectious morbidity.
povidone-iodine solution immediately prior to cesarean delivery reduces postcesarean
infectious morbidity.
Cesarean delivery is the most common surgical procedure performed on women in the US; nearly
1.3 million are performed each year. Postoperative infectious morbidity is the most common
complication of cesarean delivery. Post-cesarean infectious morbidity is often the result of
indigenous vaginal flora that ascend into the uterus at the time of surgery. Thus, reducing
vaginal microbial load may reduce post-cesarean infection. However, results from studies
assessing the role of vaginal cleansing prior to cesarean have been mixed.
The investigators will perform a randomized controlled clinical trial to test the hypothesis
that vaginal cleansing with povidone-iodine solution immediately prior to cesarean delivery
reduces postcesarean infectious morbidity.
1.3 million are performed each year. Postoperative infectious morbidity is the most common
complication of cesarean delivery. Post-cesarean infectious morbidity is often the result of
indigenous vaginal flora that ascend into the uterus at the time of surgery. Thus, reducing
vaginal microbial load may reduce post-cesarean infection. However, results from studies
assessing the role of vaginal cleansing prior to cesarean have been mixed.
The investigators will perform a randomized controlled clinical trial to test the hypothesis
that vaginal cleansing with povidone-iodine solution immediately prior to cesarean delivery
reduces postcesarean infectious morbidity.
Inclusion Criteria:
- Women undergoing cesarean delivery after labor at Barnes-Jewish Hospital.
Exclusion Criteria:
- Inability to obtain consent
- known or suspected allergy to iodine or shellfish
- women with active herpes simplex virus infection
We found this trial at
1
site
Saint Louis, Missouri 63110
Principal Investigator: Lorene A Temming, MD
Phone: 314-362-7300
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