The Miami Heart Study at Baptist Health South Florida
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - 65 |
| Updated: | 6/29/2018 |
| Start Date: | August 2014 |
| End Date: | May 2023 |
| Contact: | Khurram Nasir, MD, MPH |
| Email: | khurramn@baptisthealth.net |
| Phone: | 7866624937 |
The Miami Heart Study at Baptist Health South Florida: A Prospective Study of Sub-Clinical Cardiovascular Disease and Emerging Cardiovascular Risk Factors in Asymptomatic Young & Middle-Aged Adults
The Miami Heart Study at Baptist Health will be an observational, longitudinal and
prospective cohort study in a target population of 4000 healthy subjects (40-65 years old)
consisting of members from the Greater Miami Area (including eligible BHSF(Baptist Health
South Florida) employees). Baseline examination will consist of (1) assessment for
cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for
subclinical atherosclerosis using Coronary CT angiogram, Coronary Artery Calcium (CAC)
testing, vascular 2D/3D ultrasound, endothelial function, arterial stiffness and (3) blood
sampling for determination of traditional risk factors, advanced "omics" and biobanking.
Participants will be followed yearly via telephone, email, or mail for change in health
status with a focus on cardiovascular disease events, including acute myocardial infarction
and other forms of coronary heart disease (CHD), stroke, and congestive heart failure;
mortality; and for cardiovascular disease interventions.
The Miami Heart Study at Baptist Health is expected to identify new imaging and biological
factors associated with the presence and feature of earliest markers of subclinical
atherosclerotic disease and provide opportunities for discovery/validation of novel
biomarkers to identify these high-risk features. This is expected to lead to advances in
understanding of evolution and progression of atherosclerotic cardiovascular disease starts
with an ultimate goal of establishing more personalized, evidence-based approach to medical
care.
prospective cohort study in a target population of 4000 healthy subjects (40-65 years old)
consisting of members from the Greater Miami Area (including eligible BHSF(Baptist Health
South Florida) employees). Baseline examination will consist of (1) assessment for
cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for
subclinical atherosclerosis using Coronary CT angiogram, Coronary Artery Calcium (CAC)
testing, vascular 2D/3D ultrasound, endothelial function, arterial stiffness and (3) blood
sampling for determination of traditional risk factors, advanced "omics" and biobanking.
Participants will be followed yearly via telephone, email, or mail for change in health
status with a focus on cardiovascular disease events, including acute myocardial infarction
and other forms of coronary heart disease (CHD), stroke, and congestive heart failure;
mortality; and for cardiovascular disease interventions.
The Miami Heart Study at Baptist Health is expected to identify new imaging and biological
factors associated with the presence and feature of earliest markers of subclinical
atherosclerotic disease and provide opportunities for discovery/validation of novel
biomarkers to identify these high-risk features. This is expected to lead to advances in
understanding of evolution and progression of atherosclerotic cardiovascular disease starts
with an ultimate goal of establishing more personalized, evidence-based approach to medical
care.
What is this study about? The Miami Heart Study is a long term observational research study
which is designed to identify new and novel relationships between risk factors, genetics,
lifestyle behaviors and cardiovascular disease in the greater Miami area. Miami is uniquely
situated to capture a diverse, multi-ethnic population. As an employee of Baptist Health and
a very important stakeholder in Baptist Health's mission, you are being asked to take part in
this research study. The investigators expect approximately 4,000 members of the South
Florida community and/or employees of Baptist Health to participate in this study over the
next 5 years.
The research study aims to better understand heart disease and what causes it. Heart disease
often starts many years before a person has a heart attack or develops symptoms of heart
disease. This is called subclinical disease - and it refers to heart disease and the body
processes causing heart disease, at a stage before any symptoms are experienced. Although
doctors and researchers have a good understanding of heart disease in some areas, subclinical
disease is not very well understood.
Better understanding subclinical disease can allow doctors and healthcare staff to intervene
and prevent the process from developing further and causing symptomatic (with symptoms) heart
disease. Progression refers to the process by which subclinical (without symptoms) heart
disease develops into clinical (with symptoms) disease.
Therefore, the purpose of this research study is to:
- To examine the presence and severity of subclinical disease in the South Florida
community.
- To examine what unique factors contribute to development of subclinical disease and
appearance of clinical symptoms.
In the future, the investigators hope this information will allow us to better predict and
prevent the development heart disease in diverse populations. Participants will be asked to
come to the Miami Heart Study clinic for an examination that may take 4 to 6 hours to
complete. During the examination, information about the participant's health will be
collected and standard procedures routinely done a physician's office such as height, weight,
and blood pressure will be performed.
which is designed to identify new and novel relationships between risk factors, genetics,
lifestyle behaviors and cardiovascular disease in the greater Miami area. Miami is uniquely
situated to capture a diverse, multi-ethnic population. As an employee of Baptist Health and
a very important stakeholder in Baptist Health's mission, you are being asked to take part in
this research study. The investigators expect approximately 4,000 members of the South
Florida community and/or employees of Baptist Health to participate in this study over the
next 5 years.
The research study aims to better understand heart disease and what causes it. Heart disease
often starts many years before a person has a heart attack or develops symptoms of heart
disease. This is called subclinical disease - and it refers to heart disease and the body
processes causing heart disease, at a stage before any symptoms are experienced. Although
doctors and researchers have a good understanding of heart disease in some areas, subclinical
disease is not very well understood.
Better understanding subclinical disease can allow doctors and healthcare staff to intervene
and prevent the process from developing further and causing symptomatic (with symptoms) heart
disease. Progression refers to the process by which subclinical (without symptoms) heart
disease develops into clinical (with symptoms) disease.
Therefore, the purpose of this research study is to:
- To examine the presence and severity of subclinical disease in the South Florida
community.
- To examine what unique factors contribute to development of subclinical disease and
appearance of clinical symptoms.
In the future, the investigators hope this information will allow us to better predict and
prevent the development heart disease in diverse populations. Participants will be asked to
come to the Miami Heart Study clinic for an examination that may take 4 to 6 hours to
complete. During the examination, information about the participant's health will be
collected and standard procedures routinely done a physician's office such as height, weight,
and blood pressure will be performed.
Inclusion Criteria:
- Current full time/part-time employees of BHSF (occupational cohort) or resident of
Greater Miami Area for at least six months (community cohort)
- Age 40 to 65 years
- Asymptomatic individuals free of any known cardiovascular event
- Able to comprehend and sign an informed consent form
Exclusion Criteria:
- Prior history of major cardiovascular events (angina, myocardial infarction, prior
coronary revascularization)
- History of cerebrovascular disease including stroke and transient ischemic attack
(TIA)
- History of peripheral arterial disease (PAD)
- History of either diagnosis or surgery for Abdominal Aortic Aneurysm (AAA)
- Heart failure
- Weight greater than 350 lbs
- Any contraindication to CT scans or iodinated contrast
- Active treatment for cancer
- Currently pregnant, breastfeeding, or suspect they may be pregnant.
- Patients who do not agree to an informed consent
We found this trial at
1
site
9555 Southwest 162nd Avenue
Miami, Florida 33196
Miami, Florida 33196
Principal Investigator: Khurram Nasir, MD,MPH
Phone: 786-662-4937
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