Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers

Conditions:Atrial Fibrillation
Therapuetic Areas:Cardiology / Vascular Diseases
Age Range:18 - 85
Start Date:October 2014
End Date:October 2016

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A Study of the Effects of BMS-919373 on Atrial Effective Refractory Period in Subjects With a Dual-Chamber Pacemaker

To determine the effect of our compound (BMS-919373) on electrical activity of the heart
using pacemakers.

For more information regarding BMS clinical trial participation, please visit

Inclusion Criteria:

- Age 18 years to 85 years

- Eligible patients will have a dual-chamber permanent pacemaker

- Women who are not of childbearing potential

Exclusion Criteria:

- Patients with a history of Atrial Fibrillation (AF) that is either

- (i) Permanent (i.e. patients are only in AF and never in sinus rhythm) or

- (ii) Persistent (i.e. patients who's episodes of AF are longer than 7 days and
require medical intervention, such as electrical or medical cardioversion, to
return to sinus rhythm), are excluded

- History of Transient Ischemic Attack (TIA) or stroke in the last 12 months

- History of clinically significant ventricular arrhythmia (not including isolated
monomorphic Premature Ventricular Contractions (PVCs)). Such arrhythmias are marked
by loss of consciousness, emergent cardioversion or defibrillation or unstable vital
signs requiring medical intervention

- Complete heart block

- Planned surgery, endovascular intervention or cardioversion within the study period

- History of atrial fibrillation
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Austin, Texas 78701
Austin, TX
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Calgary, Alberta
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