Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery



Status:Recruiting
Conditions:Post-Surgical Pain, Hospital
Therapuetic Areas:Musculoskeletal, Other
Healthy:No
Age Range:18 - 70
Updated:4/21/2016
Start Date:August 2015
Contact:Rachel Kim
Email:rkim@kcrnresearch.com

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A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectal Surgery

The purpose of this Phase 2 study is to evaluate the efficacy and safety of an analgesic
drug candidate, VVZ-149 Injections. The study is designed as randomized, double-blind,
parallel, placebo-controlled study.

VVZ-149 is a dual antagonist of GlyT2 and 5HT2A. GlyT2 blockage increases inhibitory
synaptic transmission by glycine in the spinal cord, resulting in a reduction of pain
transmissions to the brain. 5HT2A blockage decreases descending serotonergic facilitatory
modulation on pain transmission by the brain and reduces nociceptor activation in peripheral
nerves, which are primary sources of pain in post-surgical pain. VVZ-149 has been shown to
have comparable efficacy to morphine in well controlled (blind, complete randomization with
a positive control) animal studies using rat models of post-operative pain and
formalin-induced pain. The PK/PD study in animals indicates that therapeutic plasma
concentration in human subjects will be 600-1,900 ng/ml. A clinical Phase 1 study performed
in healthy subjects has shown no clinically significant adverse events up to a plasma
concentration level of 3,261 ng/ml other than brief symptoms of mild nausea or dizziness,
and mild somnolence when the plasma exposure level is more than 2,000 ng/ml.

Inclusion Criteria:

1. Men and women age between 18-70, inclusive.

2. Pain intensity (NRS) ≥4 at initial post-operative measurement in PACU.

3. Subjects undergoing planned laparoscopic colorectal surgery.

4. Ability to provide written informed consent.

5. Ability to understand study procedures and communicate clearly with the investigator
and staff.

6. American Society of Anesthesiologists (ASA) risk class of I to III.

Exclusion Criteria:

< Surgical Factors >

1. Emergency or unplanned surgery.

2. Repeat operation (e.g., previous surgery within 30 days for same condition).

3. Cancer-related condition causing preoperative pain in site of surgery.

< Subject Characteristics >

4. Women with childbearing potential (Women age 18-55 must undergo pregnancy test).

5. Women who are pregnant or breastfeeding.

6. Chronic pain diagnosis (e.g., ongoing pain at baseline with NRS ≥ 4/10).

7. Unstable or poorly controlled psychiatric condition (e.g., untreated PTSD, anxiety,
or depression) Subjects who take stable doses (same dose >30 days) of antidepressants
and anti-anxiety drugs may be included.

8. Unstable or acute medical condition (e.g., unstable angina, congestive heart failure,
renal failure, hepatic failure, AIDS).

< Drug, Alcohol, and Pharmacological Considerations >

9. Renal or hepatic impairment.

10. History of alcohol, opiate or other drug abuse or dependence within 12 months prior
to Screening (TICS alcohol/drug screen will be performed at Screening).

11. Ongoing or recent (within 30 days prior to surgery) use of steroids, opioids, or
antipsychotics.

12. Alcohol consumption within 24 hours of surgery.

13. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen within 24 hours
of surgery.

14. Use of herbal agents or nutraceuticals (i.e., chaparral, comfrey, germander, jin bu
huan, kava, pennyroyal, skullcap, St. John's wort, or valerian) within 7 days prior
to surgery.

< Anesthetic and Other Exclusion Considerations >

15. Use of neuraxial or regional anesthesia related to the surgery.

16. Use of local anesthetic wound infiltration > 20 ml of 1% lidocaine

17. Use of ketamine, gabapentin, pregabalin, or lidocaine (>1 mg/kg) intra or
peri-operatively, or within 24 hours of surgery.

18. Subjects with known allergies to hydromorphone.

19. Subjects who received another investigational drug within 30 days of scheduled
surgery.

20. Subjects who have long PR (>200 msec) or prolonged QTc (> 450 msec) at Screening or
on an EKG done immediately prior to dosing.
We found this trial at
3
sites
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Natacha Zamor, MD
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Sheldon Bao, MD
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Srdjan Nedeljkovic, MD
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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