Mesenchymal Stem Cell Augmentation in Patients Undergoing Arthroscopic Rotator Cuff Repair

Rotator cuff repair is one of the most commonly performed arthroscopic procedures in the
United States, but re-tear remains a common long-term complication. This can lead to pain,
decreased shoulder function, and the need for corrective surgery. Mesenchymal stem cells have
been shown to improve healing rates in arthroscopic rotator cuff repair, primarily due to
their retained ability to differentiate into several different adult cell lines, such as
tenocytes, chondrocytes, and osteoblasts. MSCs further enhance the healing process by
releasing growth factors into the local environment to promote tissue regeneration.

While MSC augmentation of arthroscopic rotator cuff repair has led to higher rates of healing
and improved tendon integrity, there remains a paucity of data surrounding clinical
improvement after the procedure. Outcomes such as post-operative strength, range of motion,
and shoulder function have yet to be compared with standard rotator cuff repair. The
incidence of post-operative persistent structural defects in the tendon after MSC
augmentation must also be further elucidated.

Inclusion Criteria:

- Patient is determined to have a full thickness rotator cuff tear (1-3 cm) or partial
tear converted to a full-thickness tear-on the pre-operative MRI scan or found
arthroscopically—and is scheduled to undergo surgical repair

- Written informed consent is obtained

Exclusion Criteria:

- Revision surgery

- Irreparable tear or partial repair

- Any patient lacking decisional capability

- Subscapularis involvement