Motor Training in PD
| Status: | Recruiting |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 3/13/2019 |
| Start Date: | November 3, 2014 |
| End Date: | December 31, 2019 |
| Contact: | Madeleine Hackney, PhD |
| Email: | madeleine.hackney@va.gov |
| Phone: | (404) 321-6111 |
Optimizing Motor Training in Parkinson Disease Through Neural Mechanisms (NEURODEGEN)
The purpose of this research study is to learn more about brain activity when individuals
with and without Parkinson disease (PD) move their lower limbs. The investigators also want
to see if and how two different types of partnered dance affect brain activity in individuals
with and without PD. Testing will take place at the Atlanta VA Medical Center and at Emory
University. The investigators expect to enroll about 140 people for this study over a
five-year period.
with and without Parkinson disease (PD) move their lower limbs. The investigators also want
to see if and how two different types of partnered dance affect brain activity in individuals
with and without PD. Testing will take place at the Atlanta VA Medical Center and at Emory
University. The investigators expect to enroll about 140 people for this study over a
five-year period.
Persons with Parkinson's disease (PD) have impaired mobility, which adversely affects their
quality of life. The effectiveness of adapted tango dance, in which participants both lead
(internally guide: IG) and follow (externally guide: EG) movement has been shown. To improve
outcomes in those with PD, the underlying brain mechanisms for both motor impairments and
improvement must be studied. IG and EG movements have distinct brain activity patterns.
Individuals with PD have trouble with IG movement but this problem is helped by strategies
used while "leading." During "following", participants with PD can use many external cues,
which helps movement in PD, because EG tasks bypass the basal ganglia, the part of the brain
affected by PD. In older persons with PD, the investigators aim to:
- determine brain activation patterns during IG and EG foot movement.
- look into effects of IG and EG training on brain activation along with mobility
improvements.
The investigators will begin with a functional Magnetic Resonance Imaging test in a scanner.
The investigators will look at brain area correlates of a clinically-used foot-tapping task,
during IG and EG conditions in older persons with and without PD. Then, the investigators
will assess the relative effectiveness of IG versus EG training during an adapted tango
class, compared to a group that participates in health education, for improved mobility and
foot tapping. Participants with PD will be assessed for disease severity. They will receive
tests of outcome measures while "OFF" and "ON" PD-specific medications at the following time
points:
- 1 week before training
- 1 week after training
- 1 month after training Participants must attend 20 lessons of IG or EG adapted tango in
12 weeks, taught by an experienced instructor. In the functional MRI (fMRI) scanner, the
investigators will assess participants for improved foot tapping after training. The
investigators will also look at changes in activation in specific brain circuits along
with training effects upon mobility.
The long-term goal is to improve motor training as much as possible for persons with PD by
understanding foot movement brain circuitry in PD as well as brain changes in circuitry
through which training is effective. This work proposes to illumine information about brain
function that is very important to continued progress in rehabilitative care of persons with
PD.
quality of life. The effectiveness of adapted tango dance, in which participants both lead
(internally guide: IG) and follow (externally guide: EG) movement has been shown. To improve
outcomes in those with PD, the underlying brain mechanisms for both motor impairments and
improvement must be studied. IG and EG movements have distinct brain activity patterns.
Individuals with PD have trouble with IG movement but this problem is helped by strategies
used while "leading." During "following", participants with PD can use many external cues,
which helps movement in PD, because EG tasks bypass the basal ganglia, the part of the brain
affected by PD. In older persons with PD, the investigators aim to:
- determine brain activation patterns during IG and EG foot movement.
- look into effects of IG and EG training on brain activation along with mobility
improvements.
The investigators will begin with a functional Magnetic Resonance Imaging test in a scanner.
The investigators will look at brain area correlates of a clinically-used foot-tapping task,
during IG and EG conditions in older persons with and without PD. Then, the investigators
will assess the relative effectiveness of IG versus EG training during an adapted tango
class, compared to a group that participates in health education, for improved mobility and
foot tapping. Participants with PD will be assessed for disease severity. They will receive
tests of outcome measures while "OFF" and "ON" PD-specific medications at the following time
points:
- 1 week before training
- 1 week after training
- 1 month after training Participants must attend 20 lessons of IG or EG adapted tango in
12 weeks, taught by an experienced instructor. In the functional MRI (fMRI) scanner, the
investigators will assess participants for improved foot tapping after training. The
investigators will also look at changes in activation in specific brain circuits along
with training effects upon mobility.
The long-term goal is to improve motor training as much as possible for persons with PD by
understanding foot movement brain circuitry in PD as well as brain changes in circuitry
through which training is effective. This work proposes to illumine information about brain
function that is very important to continued progress in rehabilitative care of persons with
PD.
Inclusion Criteria:
- Age 40 - 70 years
- Willingness to spend 1-h in a scanner
- Able to walk with or without an assistive device 10 feet
- Best corrected/aided acuity better than 20/70 in the better eye
- Absence of dementia or vascular cognitive impairment
- Absence of primary memory deficits
Exclusion Criteria:
- Deep brain stimulator implants, Metallic implants, fragments, or pacemakers
- Montreal Cognitive Assessment (MocA) score < 24
- Pure-tone threshold sensitivity > 40 dB
- Peripheral neuropathy
- Untreated Major Depression
- History of stroke, or traumatic brain injury
We found this trial at
1
site
Decatur, Georgia 30033
Principal Investigator: Madeleine Hackney, PhD
Phone: 404-321-6111
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