A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/1/2018 |
| Start Date: | August 2015 |
| End Date: | January 2018 |
neoMONARCH: A Phase 2 Neoadjuvant Trial Comparing the Biological Effects of 2 Weeks of Abemaciclib (LY2835219) in Combination With Anastrozole to Those of Abemaciclib Monotherapy and Anastrozole Monotherapy and Evaluating the Clinical Activity and Safety of a Subsequent 14 Weeks of Therapy With Abemaciclib in Combination With Anastrozole in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer
The purpose of this study is to evaluate the biological effects of abemaciclib in combination
with anastrozole and compare those to the effects of abemaciclib alone and anastrozole alone
in the tumors of postmenopausal women with hormone receptor positive (HR+), human epidermal
growth factor receptor 2 (HER2) negative breast cancer.
with anastrozole and compare those to the effects of abemaciclib alone and anastrozole alone
in the tumors of postmenopausal women with hormone receptor positive (HR+), human epidermal
growth factor receptor 2 (HER2) negative breast cancer.
Inclusion Criteria:
- Have postmenopausal status.
- Adenocarcinoma of the breast.
- Breast tumor ≥1 centimeter (cm) in diameter, HR+, HER2-.
- Neoadjuvant endocrine monotherapy is deemed to be a suitable therapy.
- Primary breast cancer that is suitable for baseline core biopsy.
- Have adequate organ function.
Exclusion Criteria:
- Bilateral invasive breast cancer.
- Metastatic breast cancer (local spread to axillary lymph nodes is permitted).
- Inflammatory breast cancer.
- Prior systemic therapy or radiotherapy for invasive or non-invasive breast cancer in
the same breast as currently being treated.
- Prior radiotherapy to the ipsilateral chest wall for any malignancy.
- Prior anti-estrogen therapy.
We found this trial at
28
sites
Honolulu, Hawaii 96819
Principal Investigator: Jennifer Carney
Phone: 808-432-8594
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
(954) 771-8000
Principal Investigator: Zdenka Segota
Phone: 954-267-7700
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
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24 Sturtevant St
Orlando, Florida 32806
Orlando, Florida 32806
Principal Investigator: Rebecca Moroose
Phone: 321-841-2285
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Athens, Georgia 30607
Principal Investigator: Petros Nikolinakos
Phone: 706-353-2990
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1120 15th Street
Augusta, Georgia 30912
Augusta, Georgia 30912
(706) 721-0211
Principal Investigator: Shou-Ching Tang
Phone: 706-721-2505
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
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Bakersfield, California 93309
Principal Investigator: Ravi Patel
Phone: 661-322-2206
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Bend, Oregon 97701
Principal Investigator: Robert Boone
Phone: 541-706-3732
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8901 Rockville Pike
Bethesda, Maryland 20889
Bethesda, Maryland 20889
(301) 295-4000
Principal Investigator: Jeremy Perkins
Phone: 301-369-8675
Walter Reed National Military Medical Center The Walter Reed National Military Medical Center is one...
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Denver, Colorado 80203
Principal Investigator: Matthew Wiener
Phone: 303-475-5599
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Grand Junction, Colorado 81501
Principal Investigator: Mark Levandovsky
Phone: 970-244-7164
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Hollywood, Florida 33021
Principal Investigator: Aurelio Castrellon
Phone: 954-844-6898
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7360 W. Deschutes
Kennewick, Washington 99336
Kennewick, Washington 99336
509-783-0144
Principal Investigator: Eric Gamboa
Phone: 509-783-4637
Columbia Basin Hematology and Oncology Our collaboration with Seattle Cancer Care Alliance gives you convenient...
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9500 Gilman Dr
La Jolla, California 92093
La Jolla, California 92093
(858) 534-2230
Principal Investigator: Teresa Helsten
Phone: 858-822-6195
The University of California, San Diego UC San Diego is an academic powerhouse and economic...
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Lincoln, Nebraska 68506
Principal Investigator: Eric Avery
Phone: 402-484-4900
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757 Westwood Plaza
Los Angeles, California 90024
Los Angeles, California 90024
(310) 825-9111
Principal Investigator: Sara Hurvitz
Phone: 310-829-5471
UCLA Medical Center Founded in 1955, UCLA Medical Center became Ronald Reagan UCLA Medical Center...
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Miami, Florida 33133
Principal Investigator: Mary Villar
Phone: 305-285-0726
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New York, New York 10021
Principal Investigator: Eleni Andreopoulou
Phone: 212-821-0654
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Plantation, Florida
Principal Investigator: Elizabeth Tan-Chiu
Phone: 954-582-1850
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Redondo Beach, California 90277
Principal Investigator: David Chan
Phone: 310-750-3376
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Salt Lake City, Utah 84106
Principal Investigator: Stephen Kendall
Phone: 801-281-6864
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Santa Barbara, California 93105
Principal Investigator: Julie Taquchi
Phone: 805-898-3270
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Santa Monica, California 93454
Principal Investigator: Robert Dichmann
Phone: 805-739-3724
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450 Serra Mall
Stanford, California 94305
Stanford, California 94305
(650) 723-2300
Principal Investigator: Suleiman Massarweh
Phone: 650-724-8935
Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
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Worcester, Massachusetts 01655
Principal Investigator: Madhavi Toke
Phone: 508-334-1000
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