A Study to Evaluate the Safety, Tolerability and Immunogenicity of Ad35.RSV.FA2 Regimens Boosted With Ad26.RSV.FA2 in Healthy Adult Participants

This is a single-center, randomized (study medication assigned to participants by chance),
placebo-controlled (an inactive substance; a pretend treatment [with no drug in it] that is
compared in a clinical trial with a drug to test if the drug has a real effect),
double-blind (neither the researchers nor the participants know what treatment the
participant is receiving) and Phase 1 study in healthy participants. The study comprises a
4-week screening period; vaccination for each participant on Days 1, 85, and, 169; a 28-day
follow-up period performed after each vaccination and a final visit at Day 323 or 351.
Participants will be randomly assigned to one of the 4 treatment groups (Group 1/2/3/4) to
receive either Ad35.RSV.FA2 or Ad26.RSV.FA2 or placebo. The study duration will be
approximately 52 weeks. Blood samples for immunogenicity will be collected. Participant's
safety will be evaluated throughout the study.

Inclusion Criteria:

- Participant must be in good health, without significant medical illness, on the basis
of physical examination, medical history, vital signs measurement, and 12-lead
electrocardiogram (ECG) performed at screening

- Participant must meet protocol defined laboratory criteria within 28 days before Day
1

- Before randomization, a woman must be either; Not of childbearing potential:
postmenopausal or surgically sterilized; of childbearing potential and practicing an
effective method of birth control before vaccination and through 3 months after the
last vaccination. Women, who are not heterosexually active at screening, must agree
to utilize highly-effective methods of birth control if they become heterosexually
active until 3 months after receiving the last dose of study vaccine

- A woman must have a negative serum pregnancy test (beta-human chorionic gonadotropin
[beta-hCG]) at the screening visit, and a negative urine pregnancy test
pre-vaccination on Day 1

- A woman must agree not to donate eggs (ova, oocytes) for the purposes of assisted
reproduction until 3 months after receiving the last dose of study vaccine. A man
must agree not to donate sperm until 3 months after receiving the last dose of study
vaccine

Exclusion Criteria:

- Participant has a body mass index (BMI) less than or equal to (<=)19 and greater than
or equal to (>=30) kilogram per square meter (kg/m2)

- Participant has any clinically significant acute or chronic medical condition that,
in the opinion of the investigator, would preclude participation (e.g. history of
seizure disorders, bleeding/clotting disorder, autoimmune disease, active malignancy,
poorly controlled asthma, active tuberculosis or other systemic infections)

- Participant has had major surgery within the 4 weeks prior to randomization or has
planned major surgery through the course of the study

- Participant has chronic active hepatitis B or hepatitis C infection, documented by
hepatitis B surface antigen and hepatitis C antibody, respectively

- Participant has human immunodeficiency virus (HIV) type 1 or type 2 infection