A Study of LY2951742 in Participants With Chronic Cluster Headache



Status:Active, not recruiting
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 65
Updated:9/29/2018
Start Date:June 18, 2015
End Date:July 22, 2019

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A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 With a Long-Term Open-Label Extension in Patients With Chronic Cluster Headache

The main purpose of this study is to evaluate the efficacy of the study drug known as
LY2951742 in participants with chronic cluster headache.


Inclusion Criteria:

- Participants with a history of chronic cluster headache occurring without a remission
period, or with remissions lasting <1 month, for at least 1 year.

- Participants are able to distinguish cluster headache attacks from other headaches.

Exclusion Criteria:

- Current enrollment in or discontinuation within the last 30 days from, a clinical
trial involving any investigational drug or device.

- Current use or any prior exposure to any calcitonin-gene-related peptide (CGRP)
antibody, any antibody to the CGRP receptor, or antibody to nerve growth factor (NGF).

- Are taking indomethacin and/or are suspected of having another distinct trigeminal
autonomic cephalalgia.

- A history of migraine variants that could implicate or could be confused with
ischemia.

- Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
proteins.

- A history or presence of other medical illness that indicates a medical problem that
would preclude study participation.

- Evidence of significant active or unstable psychiatric disease, in the opinion of the
investigator.

- Women who are pregnant or nursing.
We found this trial at
14
sites
Stanford, California 94303
Principal Investigator: Nada Hindiyeh
Phone: 650-497-6810
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1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
Principal Investigator: Kavita Kalidas
Phone: 813-844-7900
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
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Ann Arbor, Michigan 48104
Principal Investigator: Joel Saper
Phone: 734-677-6000
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Bellevue, Washington 98007
Principal Investigator: Arifulla Khan
Phone: 425-453-0404
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Dallas, Texas 75390
Principal Investigator: Deborah Friedman
Phone: 214-648-3517
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Englewood, Colorado
Principal Investigator: Cori Millen
Phone: 720-336-4300
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Gent,
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Jacksonville, Florida 32216
Principal Investigator: Todd Rozen
Phone: 904-953-0853
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Jacksonville, FL
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Morgantown, West Virginia
Principal Investigator: David Watson
Phone: 304-598-6127
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333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Principal Investigator: Christopher Gottschalk
Phone: 203-785-4085
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Stephen Silberstein
Phone: 215-955-2243
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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Phoenix, Arizona
Principal Investigator: Rashmi Halker Singh
Phone: 480-342-0881
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Santa Monica, California 90404
Principal Investigator: David Kudrow
Phone: 310-315-1456
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Stamford, Connecticut 06905
Principal Investigator: Peter McAllister
Phone: 203-914-1903
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