Resistance Training in HFpEF

In this randomized controlled pilot study of resistance exercise training in patients with
HFpEF, the investigators will recruit 24 HFpEF patients who will be randomized to resistance
exercise training (RT - n=12) or no resistance exercise training (standard care control group
[CTL] - n=12). The investigators will have baseline and follow-up measures of clinical
characteristics, leg muscle strength, quality of life, lean muscle mass (body composition via
DXA including segmental lean mass), maximal cardiopulmonary exercise test (peak VO2, peak
work, ventilatory efficiency), constant-load submaximal cardiopulmonary exercise test with
speckle tracking echocardiography (exertional dyspnea and fatigue at matched workloads,
cardiac output, diastolic function, left ventricular strain, ventilation, gas exchange, and
locomotor muscle neural feedback).

Participants will be asked to make 4 separate study visits. Those randomized to undergo
Resistance Training will be expected to make those visits as well.

All patients will be managed by their primary care physician or cardiologist with
additional review and oversight by Dr. Borlaug (Co-Investigator) prior to enrollment to
ensure adequacy of inclusion and exclusion criteria and that participation in exercise
testing and resistance exercise training is safe.

Inclusion Criteria, includes:

- Clinical diagnosis of HFpEF.

- Patients 18-80 yrs old with a history stable (no medication changes in past 6 weeks
(w/duration of diagnosis >6 months).

- New York Heart Association class I-III.

- Ejection fraction ≥40%.

- Current non-smokers with <15 pack year history.

- Non-pregnant women, and individuals who are able to exercise (i.e. without orthopedic
limitations or neuromuscular disorders).

Exclusion Criteria, includes:

- Patient refusal to participate.

- Significant orthopedic or neuromuscular limitations

- Significant cognitive impairment

- Hemoglobin < 7.0 g/d.