Acid-Base Compensation in Chronic Kidney Disease
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 22 - Any |
| Updated: | 8/31/2017 |
| Start Date: | April 2015 |
| End Date: | August 25, 2017 |
Acid-Base Compensation in Chronic Kidney Disease: Measurement and Physiologic Impact
The purpose of this study is to evaluate changes in urine net acid excretion, blood pressure
and body chemistry that occur when the dietary acid load is lowered by using a drug/dietary
supplement similar to baking soda. This may be important for patients with kidney disease
because they may have difficulty removing all of the dietary acid load from the body in the
urine. Participants with and without kidney disease will be recruited. Each participant will
be fed a controlled diet for one week with sodium bicarbonate and for one week without sodium
bicarbonate to evaluate these changes. The investigators will also determine if the effect of
dietary acid load reduction is different in patients with kidney disease compared to those
without kidney disease.
and body chemistry that occur when the dietary acid load is lowered by using a drug/dietary
supplement similar to baking soda. This may be important for patients with kidney disease
because they may have difficulty removing all of the dietary acid load from the body in the
urine. Participants with and without kidney disease will be recruited. Each participant will
be fed a controlled diet for one week with sodium bicarbonate and for one week without sodium
bicarbonate to evaluate these changes. The investigators will also determine if the effect of
dietary acid load reduction is different in patients with kidney disease compared to those
without kidney disease.
Inclusion Criteria:
- estimated glomerular filtration rate ≥30 ml/min/1.73m2
- serum bicarbonate 20-28 mEq/L
Exclusion Criteria:
- diabetes mellitus
- uncontrolled hypertension or recent (<3 weeks) titration of blood pressure medications
- clinically significant volume overload on screening physical examination
- selected medical conditions other than kidney disease and hypertension (active cancer,
chronic liver failure, moderate to severe COPD, New York Heart Association class 2 or
greater congestive heart failure, obstructive sleep apnea requiring nightly continuous
positive airway pressure, solid organ transplant)
- use of alkali supplementation
- body mass index <18.5 or >40 kg/m2
- ideal body weight <45.5 kg
- anemia at screening (hematocrit <29% in participants with kidney disease or <33% in
healthy participants)
- pregnancy or breastfeeding
- allergies, intolerance or unwillingness to consume foods or supplement provided in
feeding menu
- serum calcium less than 8.6 mg/dl on screening laboratories
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