Resistance to HIV Infection
| Status: | Recruiting |
|---|---|
| Conditions: | Infectious Disease, HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 4/2/2016 |
| Start Date: | December 1995 |
Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-Exposed Seronegative Individuals
The immune systems of some individuals may be capable of resisting HIV infection. These
individuals do not appear to be infected with HIV despite multiple sexual encounters with
HIV infected partners. This study will examine the immune systems of these individuals to
determine what factors are responsible for their ability to resist HIV infection.
Study hypothesis: Some long-term, multiply-exposed seronegative persons have relative
resistance to HIV infection maintained by T cell responses.
individuals do not appear to be infected with HIV despite multiple sexual encounters with
HIV infected partners. This study will examine the immune systems of these individuals to
determine what factors are responsible for their ability to resist HIV infection.
Study hypothesis: Some long-term, multiply-exposed seronegative persons have relative
resistance to HIV infection maintained by T cell responses.
Rare individuals appear naturally resistant to overt HIV-1 infection despite repeated sexual
exposures. These individuals, referred to as exposed seronegatives (ES), represent a unique
population in which to evaluate mechanisms by which HIV-1 replication is either controlled
or aborted. The purpose of the study is to analyze HIV-specific immune responses, both
cellular and humoral, that exist in seronegative individuals who have experienced multiple
exposures to HIV by sexual contact.
This study will follow participants for 2 years. Participants will have 25 study visits
during the study. Assessments will include HIV tests, viral load measurements, CD4 counts,
pregnancy tests, and physical exams.
exposures. These individuals, referred to as exposed seronegatives (ES), represent a unique
population in which to evaluate mechanisms by which HIV-1 replication is either controlled
or aborted. The purpose of the study is to analyze HIV-specific immune responses, both
cellular and humoral, that exist in seronegative individuals who have experienced multiple
exposures to HIV by sexual contact.
This study will follow participants for 2 years. Participants will have 25 study visits
during the study. Assessments will include HIV tests, viral load measurements, CD4 counts,
pregnancy tests, and physical exams.
Inclusion Criteria:
- Good general health
- HIV uninfected
- Repeated exposures to HIV through unprotected sexual intercourse within the 2 years
prior to study entry
- Live in the greater Seattle area
- Plan to stay in the greater Seattle area for the 2 years after study entry
Exclusion Criteria:
- Pregnancy
We found this trial at
1
site
Seattle, Washington 98104
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