Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis



Status:Recruiting
Conditions:Psychiatric, Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:15 - 30
Updated:3/21/2019
Start Date:March 2015
Contact:Sarah Pridgen, MA, LPC
Email:rushsocialbrain@gmail.com
Phone:(312) 502-2501

Use our guide to learn which trials are right for you!

Optimizing Cognitive Training to Improve Functional Outcome in Clinical High Risk (CHR)

This project is a randomized-controlled trial to test the efficacy of computer-based targeted
cognitive training (TCT) versus a placebo intervention of commercial computer games in
adolescent/young adults at clinical high risk (CHR) for psychosis. TCT is designed to
optimize learning-induced neuroplasticity in vulnerable neurocognitive systems. A main aim is
to test the hypothesis that this neuroscience-guided TCT intervention will improve neural
function, and that these neural improvements will improve cognition and functional outcome.
CHR participants will be randomly assigned to 40 hours of TCT or placebo computer games
completed within 10 weeks. TCT consists of 20 hours of training in cognition, including
processing speed, memory, attention, and cognitive control followed by 20 hours of training
in social cognition including affect recognition and theory of mind. Neuroimaging, cognition,
social cognition, clinical symptoms, and functional status will be assessed at baseline,
after 20 hours/5 weeks of cognitive training (mid-intervention), and after 20 hours/5 weeks
of social-cognitive training (post-intervention). Cognition, social cognition, symptoms, and
functioning will also be assessed at a 9 month follow-up (i.e. 9 months after intervention
completion). We predict that TCT will lead to improvements in neurocognitive function and
functional status. The results of this study will provide important information about a
benign, non-pharmacological intervention for improving cognition and functional outcome in
CHR individuals.


Inclusion Criteria:

- English speaking

- One or more psychosis-risk syndromes as defined by the Structured Interview for
Psychosis-Risk Syndromes (SIPS)

Exclusion Criteria:

- Intelligence Quotient (IQ) < 70

- Major medical illness or neurological disorder

- Lifetime history of Axis I psychotic disorder and/or clear evidence that
psychosis-risk syndrome is due to non-schizophrenia-spectrum Axis I or Axis II
disorder
We found this trial at
1
site
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Christine I Hooker, Ph.D.
Phone: 312-502-2501
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
?
mi
from
Chicago, IL
Click here to add this to my saved trials