Aromatase Inhibitors in the Treatment of Male Infertility
| Status: | Terminated |
|---|---|
| Conditions: | Obesity Weight Loss, Skin and Soft Tissue Infections, Women's Studies |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Endocrinology, Reproductive |
| Healthy: | No |
| Age Range: | 16 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | March 2007 |
| End Date: | June 2014 |
The Role of Aromatase Inhibitors in the Treatment of Infertility in Obese Male
Obesity is associated with an increase in blood levels of estrogen. Estrogen or "female
hormone" is believed to have a negative effect on sperm production. Aromatase inhibitors
such as anastrozole work to decrease the production of estrogen and increase testosterone in
the body. By decreasing the level of estrogen, sperm production should improve. In this
study, the investigators will try to determine the benefit of anastrozole in obese men and
follow pregnancy outcomes.
hormone" is believed to have a negative effect on sperm production. Aromatase inhibitors
such as anastrozole work to decrease the production of estrogen and increase testosterone in
the body. By decreasing the level of estrogen, sperm production should improve. In this
study, the investigators will try to determine the benefit of anastrozole in obese men and
follow pregnancy outcomes.
Inclusion Criteria:
1. Male partner of a couple presenting for infertility work up after one year of
unprotected intercourse
2. Moderate oligozoospermia (defined as mean sperm count ≤ 20 × 106/mL and ≥ than 3 ×
106/mL) of at least two separate occasions spanning a minimum of two weeks
3. Obese men BMI ≥ 30
4. FSH and LH levels < 10 mIU/mL
Exclusion Criteria:
1. Severe Oligozoospermia: Sperm count < than 3 × 106/mL, including azoospermia
2. Age less than 18 or greater than 65 years
3. Pyospermia or leukospermia: defined by white blood cells ≥ 1 million leukocytes per
milliliter of semen
4. Cryptorchidism
5. Vasectomy reversal
6. Regular use of tobacco products
7. BMI < 30
8. Use of anabolic steroids or testosterone replacement
9. All patients with abnormal initial liver function tests "AST or ALT" will be excluded
form the study
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