Trial of the Use of Doxycycline After Rotator Cuff Repair



Status:Not yet recruiting
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:March 2016
End Date:March 2018
Contact:Aman Dhawan, MD
Email:adhawan@hmc.psu.edu
Phone:717-531-5638

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Trial Summary
Trial Overview
Inclusion Criteria

Randomized Controlled Trial of the Use of Doxycycline After Rotator Cuff Repair

The purpose of this study is to examine healing after rotator cuff repair in subjects either
treated with Doxycycline or placebo post-operatively.

Basic Science small animal model data indicates that matrix metalloproteinase (MMP)
inhibition via doxycycline results in improved early rotator cuff repair biomechanics and
histology. Rotator cuff repair failure and retear is a significant clinical problem. The
effects of MMP inhibition on human rotator cuff tear repair healing and outcomes is unknown,
but may potentially improve healing rates and outcomes. Our purpose is to evaluate the
effects of early oral doxycycline on healing and outcomes following arthroscopic rotator
cuff repair.

Inclusion Criteria:

- repair of rotator cuff

- age 18 and above

- able to swallow capsules

Exclusion Criteria:

- less than 18

- unable to read or understand consent form

- unable to swallow capsules

- allergy to doxycycline
We found this trial at
1
site
Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Phone: 717-531-5638
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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mi
from
Hershey, PA
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