Accurate Test of Limb Isometric Strength (ATLIS) in ALS
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | March 2015 |
| End Date: | February 2020 |
| Contact: | Ashley Fetterman |
| Email: | katherine.fetterman@cshs.org |
| Phone: | 310-423-8497 |
A strength measurement device called Accurate Test of Limb Isometric Strength (ATLIS) was
developed to precisely and conveniently measure static limb strength in patients with ALS.
The investigator will compare ATLIS data with data from the commonly used ALS outcomes
measure, the ALS Functional Rating Scale-Revised (ALSFRS-R), as well as an exploratory
measure, electrical impedance myography (EIM), in a prospective, longitudinal study. Both
outcomes measures will be performed on 100 subjects collected preferably at bi-monthly clinic
visits during the study period.
developed to precisely and conveniently measure static limb strength in patients with ALS.
The investigator will compare ATLIS data with data from the commonly used ALS outcomes
measure, the ALS Functional Rating Scale-Revised (ALSFRS-R), as well as an exploratory
measure, electrical impedance myography (EIM), in a prospective, longitudinal study. Both
outcomes measures will be performed on 100 subjects collected preferably at bi-monthly clinic
visits during the study period.
Cedars-Sinai Medical Center will enroll and collect data on 100 subjects. Subjects will
ideally be tested every 1 to 4 months according to each patient's site visit schedule.
Subjects will be tested at each visit using ATLIS, the ALSFRS-R questionnaire and EIM.
ideally be tested every 1 to 4 months according to each patient's site visit schedule.
Subjects will be tested at each visit using ATLIS, the ALSFRS-R questionnaire and EIM.
Inclusion criteria:
- Subjects 18 years or older diagnosed with clinically possible, laboratory supported
probable, probable or clinically definite ALS according to the World Federation of
Neurology Revised El Escorial Criteria.
- Capable of providing informed consent and complying with trial procedures.
- Active movement of at least two limbs at the time of study entry
- Intend to routinely attend clinic for neurological care at the clinical site
Exclusion criteria:
- Patients, judged by the site clinical investigator to have medical conditions that may
limit their ability to safely exert maximal force using the muscles in their arms and
legs will be excluded from this study (e.g. unstable hypertension, significant cardiac
disease, significant musculoskeletal disorders, or other medical conditions).
- Patients judged by the site clinical investigator to have significant clinical
evidence of unstable medical or psychiatric illness will be excluded.
We found this trial at
1
site
8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Phone: 310-423-8497
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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