A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations



Status:Terminated
Conditions:Breast Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/10/2019
Start Date:February 3, 2015
End Date:January 14, 2016

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PHASE 2 STUDY OF SINGLE-AGENT PF-03084014 IN PATIENTS WITH ADVANCED TRIPLE-NEGATIVE BREAST CANCER WITH OR WITHOUT GENOMIC ALTERATIONS IN NOTCH RECEPTORS

This study is designed to evaluate the preliminary anti-tumor activity and tolerability of
PF-03084014 when administered as a single agent in the treatment of patients with advanced
triple receptor-negative breast cancer (mTNBC) harboring genomic alterations in Notch
receptors (NA+), and in a smaller subset of mTNBC patients whose tumor tests negative for
genomic alterations in Notch receptors (NA-)


Inclusion Criteria:

- Histological or cytological diagnosis of triple negative breast cancer (TNBC) with
evidence of a) metastatic or b) locally recurrent advanced disease that is not
amenable to resection or radiotherapy with curative intent.

- Availability of an original diagnostic tumor tissue or the most recent metastatic
tumor biopsies (archival biopsy or de novo biopsy) and a peripheral blood sample for
Notch receptors genomic profiling

Exclusion Criteria:

- Known brain metastases.

- Prior treatment with gamma secretase inhibitor or other Notch signaling inhibitor.
We found this trial at
19
sites
Stanford, California 94305
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136 Mountainview Blvd
Basking Ridge, New Jersey 7920
(908) 542-3000
Memorial Sloan-Kettering Cancer Center - Basking Ridge At Memorial Sloan Kettering Basking Ridge, we offer...
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Basking Ridge, NJ
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Boston, Massachusetts 02115
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Boston, MA
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Boston, Massachusetts 02115
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Boston, MA
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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650 Commack Rd
Commack, New York 11725
(631) 623-4000
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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Commack, NY
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Debrecen,
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500 Westchester Avenue
Harrison, New York 10604
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Harrison, NY
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New Lenox, IL
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1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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Paramus, New Jersey 07652
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Paramus, NJ
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Paramus, New Jersey 07652
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Paramus, NJ
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Rockville Centre, NY
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Sleepy Hollow, NY
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Stanford, California 94305
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Stanford, CA
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Stanford, California
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Stanford, CA
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Westwood, New Jersey 07675
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Westwood, NJ
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Zion, Illinois 60099
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Zion, IL
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