Understanding the Relationship Between Inflammation and Insulin Resistance in the Adipose Tissue

Status:Active, not recruiting
Conditions:Obesity Weight Loss, Endocrine
Therapuetic Areas:Endocrinology
Age Range:30 - 50
Start Date:August 2014
End Date:January 2019

Use our guide to learn which trials are right for you!

Immunomodulatory Role of Eosinophils in Determining Inflammation and Insulin Sensitivity in Human Adipose Tissue- Aims 1&2

This study is being done to better understand the relationship between inflammation and
insulin resistance in your Adipose (fat) Tissue .

This study is being done to determine whether eosinophils (a type of white blood cell) play
an important role in human fat metabolism and inflammation.

This study is being done to determine if fish oil supplement could play a role in reducing
inflammation and improving insulin sensitivity in your fat tissue.

Lean, healthy person with a body mass index (BMI) of 25 or less, or you are obese, BMI
between 30 and 50, and non-diabetic.

Lean healthy controls will not be on any medication and will be undergoing elective
abdominal surgery excluding those involving acute inflammation (i.e. acute cholecystitis,
bowel perforation, or diverticulitis).

Obese, non-diabetic subjects will have a BMI between 30 and 50 and be taking no medications
affecting glucose metabolism or lipid metabolism. These subjects will be identified from a
pool of patients undergoing an elective abdominal surgical procedure such as inguinal
hernia repair, laparoscopic Nissen fundoplication, planned cholecystectomy, but also
bariatric surgery.

Volunteers will not be taking corticosteroid therapy or have a history of asthma, COPD or
atopic syndrome. All subjects will undergo a medical history intake and a physical
examination followed by an OGTT to confirm normal glucose.
We found this trial at
13400 E. Shea Blvd.
Scottsdale, Arizona 85259
Principal Investigator: Elena De Filippis, MD PhD
Phone: 480-301-4626
Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
Scottsdale, AZ
Click here to add this to my saved trials