Oral Alkali Production and Caries Prevention in Children (Cross-sectional Component)
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Dental |
| Therapuetic Areas: | Dental / Maxillofacial Surgery, Other |
| Healthy: | No |
| Age Range: | 2 - 5 |
| Updated: | 4/21/2016 |
| Start Date: | March 2015 |
| End Date: | September 2015 |
The fact that dental caries remains a major public health problem mandates that oral-health
researchers explore new strategies for assessment of caries risk, as well as for caries
prevention and management. Dental caries occurs when acids produced by bacterial glycolysis
of dietary carbohydrates causes demineralization of the tooth enamel. A major focus of
caries research has been on identifying and characterizing acid-generating bacteria and the
mechanisms of acid resistance. The purpose of this study is to investigate the type of
bacteria that grows in the mouth and on teeth.
researchers explore new strategies for assessment of caries risk, as well as for caries
prevention and management. Dental caries occurs when acids produced by bacterial glycolysis
of dietary carbohydrates causes demineralization of the tooth enamel. A major focus of
caries research has been on identifying and characterizing acid-generating bacteria and the
mechanisms of acid resistance. The purpose of this study is to investigate the type of
bacteria that grows in the mouth and on teeth.
This study will require only one visit. The study visit will last about one hour. At the
study visit, parent-administered questionnaires will be used to collect information on the
following: (a) the participant's demographic background (age, gender, and race), (b)
socio-economic status (parents' income and housing condition), (c) participant's oral health
practice (feeding histories, diet habits, oral hygiene measures, and dental attendance), and
(d) systemic diseases. During the study visit, the participant's complete medical and dental
history will be obtained and reviewed, and a dental exam will be performed in order to
determine participants' caries status, and intraoral pictures may be taken of participants'
teeth.
Participants will not be allowed to brush or clean teeth using any type of oral hygiene
procedures for 8 hours prior to sample collection. Saliva and plaque (The solf
white-yellowish material on the tooth surface) will be collected. The Investigator will use
a small probe to measure the pH of the dental plaque that builds up on the teeth. The
participant will be asked to dip one finger into a glass containing a buffer solution and
the probe will be placed on the teeth from which plaque will be taken.
Dental plaque will be collected from the participants between the ages of 2 and 5 with at
least two teeth and who allow the dental examination and the sample collection procedures to
be done safely. Plaque samples will be collected by gently scrapping the tooth using a
sterile instrument. If the participant does not have enough plaque samples, they will be
asked to return on the following day. Saliva will be collected by using cotton swabs or by
asking the participant to spit into a sterile plastic container.
study visit, parent-administered questionnaires will be used to collect information on the
following: (a) the participant's demographic background (age, gender, and race), (b)
socio-economic status (parents' income and housing condition), (c) participant's oral health
practice (feeding histories, diet habits, oral hygiene measures, and dental attendance), and
(d) systemic diseases. During the study visit, the participant's complete medical and dental
history will be obtained and reviewed, and a dental exam will be performed in order to
determine participants' caries status, and intraoral pictures may be taken of participants'
teeth.
Participants will not be allowed to brush or clean teeth using any type of oral hygiene
procedures for 8 hours prior to sample collection. Saliva and plaque (The solf
white-yellowish material on the tooth surface) will be collected. The Investigator will use
a small probe to measure the pH of the dental plaque that builds up on the teeth. The
participant will be asked to dip one finger into a glass containing a buffer solution and
the probe will be placed on the teeth from which plaque will be taken.
Dental plaque will be collected from the participants between the ages of 2 and 5 with at
least two teeth and who allow the dental examination and the sample collection procedures to
be done safely. Plaque samples will be collected by gently scrapping the tooth using a
sterile instrument. If the participant does not have enough plaque samples, they will be
asked to return on the following day. Saliva will be collected by using cotton swabs or by
asking the participant to spit into a sterile plastic container.
Inclusion Criteria:
- Age 2 to 5 years
Exclusion Criteria:
- Treated with antibiotics within the past 3 months
- taking any medication at the time of the study
- uses orthodontic appliance, and
- has performed oral hygiene procedures in the past 8 hour prior to the collection
appointment.
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