Transplant Optimization Using Functional Imaging
| Status: | Completed |
|---|---|
| Conditions: | Bronchitis, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/30/2017 |
| Start Date: | February 2015 |
| End Date: | January 9, 2017 |
The objective of this study is to detect Bronchiolitis Obliterans Syndrome (BOS) in an early
stage using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust
and automated segmentation algorithms will be developed for these parameters, focusing on
quantitative computed tomography (CT) image analyses to provide the physician a more
sensitive diagnostics tool. The evolution of BOS over time will be monitored using non-rigid
image registration methods.
stage using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust
and automated segmentation algorithms will be developed for these parameters, focusing on
quantitative computed tomography (CT) image analyses to provide the physician a more
sensitive diagnostics tool. The evolution of BOS over time will be monitored using non-rigid
image registration methods.
Inclusion Criteria:
- Male or female patient ≥ 18 years old
- Written informed consent obtained
- Patient who had undergone a lung transplant a year ago or more.
- Female patient of childbearing potential who confirm that a contraception method was
used at least 14 days before visit 1 and will continue to use a contraception method
during the study
- The patient must be able to perform the lung monitoring at home.
Exclusion Criteria:
- Pregnant or lactating female
- Known history of or active airways or anastomotic complications requiring
intervention such as stenting or dilation
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Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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