Individual Differences in Drug Response

This study will assess a broad range of potential outcomes related to administration of a
double-blinded, but FDA-approved study medication. Participants will be required to spend the
night on a clinical research unit, located on the Johns Hopkins Bayview Medical Campus, for 4
consecutive nights (Monday - Friday). Participants will undergo daily sessions Tuesday -
Friday. Tuesday sessions will consist of taking a study medication in the morning and
afternoon, and completing a pain testing session after each study drug administration.
Wednesday through Friday sessions will consist of taking a study drug in the morning and
providing self-report ratings of drug effects and vital sign measurements (such as blood
pressure, pulse) several times for a 6-hour period. The investigators will also collect
saliva samples to assess physiological functioning, and will ask you to complete a
computerized task to assess levels of functioning.

Inclusion Criteria:

- Healthy adults (21 or older) able to participate in a 5-day residential study

Exclusion Criteria:

- Being contraindicated for blinded study drug; chronic pain; illicit drug use;
pregnancy or breastfeeding