Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis



Status:Recruiting
Conditions:Neurology, Multiple Sclerosis
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:7 - 110
Updated:4/21/2016
Start Date:August 1991
End Date:January 2017
Contact:Jacqueline Smith
Email:Jacqueline.Smith4@nyumc.org
Phone:212-263-3335

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Quantitative MR Imaging and Proton Spectroscopy in MS

The primary purpose of this study is to detect changes in the brain that may be associated
with multiple sclerosis. Results will be compared to age matched controls. Investigators
will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization
transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and
secondary-progressive disease. This data will be correlated to total brain parenchymal
volume as well as identifying the effect of MS lesions on the gray and white matter,
volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a
specific battery of neuropsychological tests. Quantitative analysis of whole brain
N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and
compare the results to age-matched controls over duration of 5 years.


Inclusion Criteria:

1. Patients with known MS diagnosis

2. Age 7-110 years

3. Males or females

Exclusion Criteria:

1. Medically unstable

2. Artificial implants in the body

3. Pregnant

Normal Controls
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Phone: 212-263-3335
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