Fluoxetine vs Aripiprazole Comparative Trial (FACT)

To Compare Fluoxetine and Aripiprazole on All-cause Discontinuation/Need to Add Another
Psychiatric Medication, Symptomatic Improvement, and Adverse Effects

Inclusion Criteria:

- consent obtained from patients and their parents (assent for patients under 18);

- age 12-25 years (inclusive);

- English-speaking;

- at least one positive (Scale A) SOPS score of 3-5, i.e., moderate, moderately severe
or severe.

Exclusion Criteria:

- lifetime diagnosis of an Axis I psychotic disorder, including: schizophreniform
disorder, schizophrenia, schizoaffective disorder, bipolar disorder, or major
depression with psychotic features;

- current psychosis (any positive symptom SOPS score of 6, i.e., extreme);

- current diagnosis of Major Depressive Disorder, single episode or recurrent, severe
without psychotic features;

- current stimulant treatment;

- history of neurological, neuroendocrine or other medical condition known to affect the
brain;

- any significant medical condition that contra-indicates treatment with either
aripiprazole or fluoxetine;

- past or current substance dependence; sunstance abuse within the last 4 weeks;

- IQ < 70.