Gabapentin in Reducing the Need for Pain Medication in Patients With Bladder Cancer Undergoing Radical Cystectomy

PRIMARY OBJECTIVES:

I. To assess if perioperative gabapentin will decrease post-operative analgesic requirements
within the first 48 hours after radical cystectomy (RC) in patients undergoing RC as measured
morphine equivalents.

SECONDARY OBJECTIVES:

I. To assess patient self-assessment of postoperative pain on Numeric Pain Scale (NPS) at 24
and 48 hours.

II. To assess time to return of bowel function (ROBF).

III. To assess length of stay (LOS) following RC.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive gabapentin orally (PO) thrice daily (TID) for 48 hours after surgery.

ARM II: Patients receive placebo PO TID for 48 hours after surgery.

Inclusion Criteria:

- Diagnosis of bladder cancer

- Anticipated radical cystectomy with ileal conduit or orthotopic neobladder

Exclusion Criteria:

- Presence of spinal cord injury including any form of paraplegia or quadriplegia

- Allergy to gabapentin

- Active alcohol dependence, defined as 2 or more positive questions on the CAGE
alcoholism questionnaire

- Illicit drug use (excluding recreational marijuana)

- Chronic kidney disease with glomerular filtration rate < 30 ml/min

- Pregnancy: All female patients < 55 years old (yo) will be administered a urine
pregnancy test prior to enrollment

- Non-English speaking patients

- Chronic gabapentin, or the similar drug pregabalin, use

- Chronic narcotic use (daily or near daily use for > 90 days)