Rifaximin Therapy in Chronic Kidney Disease



Status:Completed
Conditions:Renal Impairment / Chronic Kidney Disease
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:18 - Any
Updated:3/8/2019
Start Date:May 2015
End Date:March 1, 2019

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Impact of Rifaximin Therapy on Intestinal Byproducts in Chronic Kidney Disease

The purpose of this study is to determine if Rifaximin decreases serum and urine levels of
bacterial byproducts and inflammatory markers in patients with chronic kidney disease and to
evaluate changes in the bacterial content of the stool from these individuals.


Inclusion Criteria:

- Chronic kidney disease with eGFR ≤ 39 ml/min/1.73m2

Exclusion Criteria:

- Patients with normal renal function or those with less advanced kidney disease

- Inability or unwillingness to provide consent

- Patients undergoing hemodialysis or peritoneal dialysis therapy or those who have
undergone organ transplant

- Patients who may be pregnant

- Hemodynamically unstable patients

- Patients with liver failure, pancreatic insufficiency, or inflammatory bowel disease

- Patients with ongoing or recent infection and those with history of C-diff infection

- Patients with abnormal bowel structure secondary to surgical or anatomic variations

- Patients on certain medications including immunosuppressants, antidiarrheal agents,
bile acid sequestrants and current or recent (within the last 3 months) use of
antibiotics
We found this trial at
1
site
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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Kansas City, KS
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