Use of Cast Iron Pots to Improve Maternal Anemia
| Status: | Recruiting |
|---|---|
| Conditions: | Anemia, Anemia |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 6/16/2018 |
| Start Date: | August 2014 |
| End Date: | November 2020 |
| Contact: | Shari Gelber, MD |
| Email: | shg7001@med.cornell.edu |
| Phone: | 212-746-3182 |
Anemia of pregnancy is defined as a hemoglobin concentration of less than 11 g/dL in the
first and third trimesters, and less than 10.5 g/dL in the second trimester. The rates of
anemia are variable and depend largely on preexisting iron stores and supplementation.
Estimates from the World Health Organization report that 35% to 75% of pregnant women in
developing countries and 18% of women from industrialized countries are anemic. Maternal
anemia is associated with an increased risk of preterm birth, low birthweight, and small for
gestational age infants. Many studies have shown improvement in these outcomes with maternal
iron supplementation in cases of iron-deficiency anemia. Mounting evidence also indicates
that maternal iron deficiency in pregnancy reduces fetal iron stores, perhaps well into the
first year of life.
Anemia in pregnancy can also impact maternal morbidity and mortality. Viteri reported that
anemic pregnant women are at greater risk of death during the perinatal period and that
anemia is the major contributory or sole cause of death in 20-40% of the 500,000 maternal
deaths per year.
The need for iron averages close to 1000mg in a typical singleton gestation. This amount
considerably exceeds the iron stores of most women and will result in iron-deficiency anemia
unless supplemental iron is taken. One problem with iron supplement use is compliance,
secondary to adverse effects such as constipation and nausea. Research on the use of cast
iron pots in decreasing the incidence of iron-deficiency anemia in non-pregnant women has
been promising. These studies have demonstrated good compliance with no reported adverse
effects. The aim of our study is to determine if providing anemic women in the first
trimester of pregnancy with a cast iron pot will decrease the incidence of anemia later in
pregnancy.
Hypothesis: Cooking in cast iron pots will increase hematocrit levels in pregnancy.
first and third trimesters, and less than 10.5 g/dL in the second trimester. The rates of
anemia are variable and depend largely on preexisting iron stores and supplementation.
Estimates from the World Health Organization report that 35% to 75% of pregnant women in
developing countries and 18% of women from industrialized countries are anemic. Maternal
anemia is associated with an increased risk of preterm birth, low birthweight, and small for
gestational age infants. Many studies have shown improvement in these outcomes with maternal
iron supplementation in cases of iron-deficiency anemia. Mounting evidence also indicates
that maternal iron deficiency in pregnancy reduces fetal iron stores, perhaps well into the
first year of life.
Anemia in pregnancy can also impact maternal morbidity and mortality. Viteri reported that
anemic pregnant women are at greater risk of death during the perinatal period and that
anemia is the major contributory or sole cause of death in 20-40% of the 500,000 maternal
deaths per year.
The need for iron averages close to 1000mg in a typical singleton gestation. This amount
considerably exceeds the iron stores of most women and will result in iron-deficiency anemia
unless supplemental iron is taken. One problem with iron supplement use is compliance,
secondary to adverse effects such as constipation and nausea. Research on the use of cast
iron pots in decreasing the incidence of iron-deficiency anemia in non-pregnant women has
been promising. These studies have demonstrated good compliance with no reported adverse
effects. The aim of our study is to determine if providing anemic women in the first
trimester of pregnancy with a cast iron pot will decrease the incidence of anemia later in
pregnancy.
Hypothesis: Cooking in cast iron pots will increase hematocrit levels in pregnancy.
Research Question: Will the addition of cast iron pots to the standard of care (nutrition
counseling, food recall, prenatal vitamin, +/- iron and vit c) improve the hematocrit of
pregnant women with anemia? Study Intervention: To provide a cast iron pot to those pregnant
women with anemia who are randomized to intervention group and an aluminum pot to those women
in the control group. Women will be blinded to their allocation. Women with a qualifying
hemoglobin will meet with our nutritionist (as they would if not enrolled in the study), and
she will perform a standardized 24 hour food recall and nutrition counseling according to the
standard of care, as well as perform written informed consent. The 24 hour food recall will
be submitted to the manufacturer (Nutrition Quest) to calculate the baseline iron intake of
each subject. Subjects will be enrolled only if they can agree to incorporate the provided
pot into their cooking (in any capacity) 3x/week. Subjects will be called 1x/month and asked
about the frequency of pot use over the past month as well as their compliance with iron and
vitamin C supplements, if prescribed. Subjects will then also be contacted postpartum to
determine satisfaction with the intervention.
Outcome measure: We will be looking at hemoglobin levels in the first, second, and third
trimester as well as postpartum (which are all routinely collected labs in pregnancy).
Ferritin will be added along with routine labs at approximately 19 weeks as this is often
performed in the workup of anemia. No labs outside of routine maternal labs will be
performed.
counseling, food recall, prenatal vitamin, +/- iron and vit c) improve the hematocrit of
pregnant women with anemia? Study Intervention: To provide a cast iron pot to those pregnant
women with anemia who are randomized to intervention group and an aluminum pot to those women
in the control group. Women will be blinded to their allocation. Women with a qualifying
hemoglobin will meet with our nutritionist (as they would if not enrolled in the study), and
she will perform a standardized 24 hour food recall and nutrition counseling according to the
standard of care, as well as perform written informed consent. The 24 hour food recall will
be submitted to the manufacturer (Nutrition Quest) to calculate the baseline iron intake of
each subject. Subjects will be enrolled only if they can agree to incorporate the provided
pot into their cooking (in any capacity) 3x/week. Subjects will be called 1x/month and asked
about the frequency of pot use over the past month as well as their compliance with iron and
vitamin C supplements, if prescribed. Subjects will then also be contacted postpartum to
determine satisfaction with the intervention.
Outcome measure: We will be looking at hemoglobin levels in the first, second, and third
trimester as well as postpartum (which are all routinely collected labs in pregnancy).
Ferritin will be added along with routine labs at approximately 19 weeks as this is often
performed in the workup of anemia. No labs outside of routine maternal labs will be
performed.
Inclusion Criteria:
- Pregnant women of any age in their first trimester of pregnancy with anemia defined as
a Hemoglobin less than 11 and/or a hematocrit less than 33
- Willingness and ability to cook in provided cast iron pot at least 3x/week
- Singleton gestations
Exclusion Criteria:
- Any secondary cause of anemia including inherited and acquired hemolytic anemias
(sickle cell disease, thalessemia, malaria, etc) Inability or unwillingness to try to
use cast iron pot approximately 3x/week
- Women with severe chronic illness and high likelihood of preterm birth and/or expected
long-term hospitalizations during pregnancy. Multifetal gestations
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