The DIVINE Study: DIetary Management of Glucose VarIability iN thE ICU

Status:	Completed
Conditions:	Hospital
Therapuetic Areas:	Other
Healthy:	No
Age Range:	18 - Any
Updated:	1/28/2018
Start Date:	November 2014
End Date:	December 2016

To compare the nutritional effect on blood glucose of two commercially available enteral
diets in overweight or obese patients in the Intensive Care Unit.

Inclusion Criteria:

- New admit to the ICU and expected to remain in ICU 5 days

- Ventilator dependent up to 48 hours prior to admission to the study

- Requiring tube feeding enteral nutrition (EN) 5 days

- Expected to receive 50% of caloric needs within 72 hours

- Body Mass Index 26-45

Exclusion Criteria:

- Trauma patients

- Major surgery in past 30 days or planned for next 7 days

- Diabetes mellitus (DM) type 1

- Admitted with diagnosis of diabetic ketoacidosis as primary diagnosis

- Pregnant or lactating

- Non-functioning GI tract

- Use of parenteral nutrition in past 30 days

- Admitted with burns > 20% body surface area

- Traumatic brain injury

- Hemodynamic instability that prevents delivery of EN > 24hr

- Unable to access GI tract for feeding via tube, unable to receive EN

- Other contraindication to tube feeding

- Any other condition that would not allow patient to complete the study protocol

- Use of enteral formula at enrollment that cannot be changed to the investigational
product

We found this trial at

sites

Vanderbilt University Medical Center

1211 Medical Center Dr
Nashville, Tennessee 37232

(615) 322-5000