Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery



Status:Recruiting
Conditions:Parkinsons Disease, Neurology, Orthopedic, Psychiatric
Therapuetic Areas:Neurology, Psychiatry / Psychology, Orthopedics / Podiatry
Healthy:No
Age Range:18 - 80
Updated:10/4/2018
Start Date:December 2014
End Date:March 2019
Contact:Pamela David Gerecht, Ph.D.
Email:pamela.davidgerecht@ucdenver.edu
Phone:303-724-4134

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Sensory Gating Measured With Microelectrode Recording During Deep Brain Stimulation Surgery

Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the
motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive
Compulsive disorder (OCD). Over 100,000 patients worldwide have now been implanted with DBS
devices. Current approved methods to locate the DBS target regions in the brain use a
combination of stereotactic imaging techniques and measurements of the electrical activity of
brain cells. As part of the standard clinical technique, electrical data are collected from
individual nerve cells. The target brain region emits unique electrical signals. At certain
brain locations, during DBS surgery, additional electrical data that are generated in
response to sound will be collected. Regions of the brain that have a decreased response to
repeated sound (auditory gating) may be important DBS targets for improving thinking. The
aims are (i) during DBS surgery, in addition to EEG, use microelectrodes in the brain to find
brain regions, along the normal path to the DBS target, where auditory gating occurs and then
(ii) determine if stimulation of the identified region(s) alters auditory gating measured by
EEG. Also an additional aim (iii) is to measure electrical activity at the scalp with EEG to
characterize auditory gating in patients before and after DBS surgery and also a healthy
control population.

Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the
motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive
Compulsive disorder (OCD). Over 100,000 patients worldwide have now been implanted with DBS
devices. Current approved methods to locate the DBS target regions in the brain (subthalamic
nucleus (STN) for PD) use a combination of stereotactic imaging techniques and measurements
of the electrical activity of brain cells. As part of the standard clinical technique,
electrical data are collected from individual nerve cells --in a procedure called
microelectrode recording (MER). The target brain region emits unique electrical signals that
are detected by MER during the standard DBS surgery. MER is done at stops along the way to
the target. At the stops during DBS surgery, additional electrical data that are generated in
response to sound will be collected. Regions of the brain that have a decreased response
after repeated sound (auditory gating) may be important DBS targets for improving thinking.
The aims are to:(Aim 1A) during DBS surgery, in addition to EEG, use microelectrodes in the
brain to measure electrical activity with single unit activity (SUA) and local field
potentials (LFP) to find brain regions along the path to the DBS target where auditory gating
occurs (Aim 1A) and then determine if stimulation of the identified region(s) alters auditory
gating measured by EEG(Aim 1B); and (Aim 2) measure electrical activity at the scalp with
electroencephalography (EEG) to characterize auditory gating in patients before and after DBS
surgery and also a healthy control population.

Inclusion Criteria:

- subjects with Parkinson's Disease planning to undergo DBS surgery

- subjects without Parkinson's Disease

- subjects without a history of mental illness.

Exclusion Criteria:

- subjects with hearing impairment

- illicit drug use

- marijuana use
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