Esophageal Absorption in EoE



Status:Recruiting
Conditions:Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 80
Updated:4/21/2016
Start Date:September 2014
End Date:December 2016
Contact:Deb

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Esophageal Absorption in Eosinophilic Esophagitis

To determine how the esophagus in active and inactive stages of eosinophilic esophagitis
tranmit fluids.


Inclusion Criteria:

- Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a
combination of compatible symptoms, endoscopic findings, histology, and lack of
response to proton pump inhibitors or negative pH study

- endoscopy with esophageal and duodenal biopsies within two weeks of performance of
this study

- Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a
combination of compatible symptoms, endoscopic findings, histology, and lack of
response to proton pump inhibitors or negative pH study, and are now in histologic
remission( <15phf) by the use of steroids or the six food elimination diet.

- Volunteers will be selected for not having any history of esophageal symptoms

Exclusion Criteria:

- Vulnerable populations, such as those with diminished mental acuity, will be
excluded.

- Patients taking Nsaids within 48 hours of the d-xylose testing

- artificial sweeteners within 48 hours of the d-xylose testing

- History of IBD

- Currently smoking or history of smoking

- History of Celiac disease

- Bacterial overgrowth,

- motility disorders

- other diffuse small bowel diseases.
We found this trial at
1
site
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Principal Investigator: David A. Katzka, M.D.
Phone: 507-538-0367
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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