Exercise and Genes in Obese (EGO)



Status:Active, not recruiting
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:Any
Updated:12/9/2018
Start Date:January 2015
End Date:August 2020

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The Effect of Exercise and Genes on Energy Expenditure, Appetite and Quality of Life in Morbidly Obese Patients

Regular exercise has several positive health effects including increased physical fitness and
muscle mass. It is well known that increased muscle mass is associated with increased resting
energy expenditure which may facilitate weight loss and maintenance. Previous studies have,
however, failed to show any consistent association between the intensity of physical exercise
and energy expenditure, or relate the variance in these adaptations to genetic variability.
Whether high-intensity exercise (HIE) is associated with improved health related quality of
life in severely obese patients remains unknown.

This PhD-project is based on a planned randomised controlled study including 50 or more
treatment seeking morbidly obese patients who will be randomised to either a 24 week
moderate-intensity exercise (MIE) programme or a 24 week high-intensity exercise (HIE)
programme. The investigators main hypothesis is that patients randomised to the HIE-program
will achieve higher energy expenditure during rest and physical activity after treatment than
those allocated to the MIE-programme. In addition, the investigators hypothesise that the
HIE-group will achieve a better health related quality of life than the MIE-group after
treatment. The investigators also hypothesize that inter-individual variability in adaptation
to the two training regimens may be due to genetic factors. If the investigators hypotheses
are confirmed, this project might have beneficial clinical implications for future obesity
treatment strategies.


Inclusion Criteria:

- Treatment seeking weight stable morbidly obese patients (BMI ≥ 40 kg/m2 or BMI 35 to
39.9 kg/m2 with ≥ 1 co morbidity) attending the outpatient Obesity Center, Vestfold
Hospital Trust, will be informed about this RCT .

Exclusion Criteria:

- Uncompensated heart failure

- Recent myocardial infarction or stroke (<½ years)

- Severe arrhythmia or heart failure

- Unstable angina pectoris

- Renal failure

- Pregnancy

- Severe eating disorders

- Active substance abuse

- Being on a diet

- Taking medication known to affect appetite or metabolism (including thyroxin).
We found this trial at
2
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Horten, Raveien
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Horten,
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Durham, North Carolina 27710
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Durham, NC
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