A Controlled Comparison of Pulsed Radiofrequency Vs Physical Therapy on Treating Chronic Knee Osteoarthritis

Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Age Range:18 - Any
Start Date:April 2014
Contact:Ronald Takemoto, M.D.

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It is estimated that nearly 27 million US adults have osteoarthritis (OA) and suffer from
pain . Pulsed Radio Frequency (PRF) is one method that has been successfully used in
treatment of various etiologies of pain. However there are limited studies and research that
prove its effectiveness in treating articular pain. The proposed study's primary aim is
determining if PRF is an effective treatment for chronic osteoarthritic knee pain. This
study hypothesizes that PRF has analgesic properties immediately after treatment and at
least 3 months afterwards compared to control treatment with physical therapy.

Additionally this research project addresses several other objectives including:

1. Provide a controlled study to determine the effectiveness of PRF for intra-articular

2. Determine how effective PRF is 1 month and 3 months after treatment for articular pain.

3. Further scientific evidence on the overall effectiveness of PRF

4. Provide evidence that PRF likely has other mechanism of action besides direct nerve
stimulation of inhibitory pain pathways.

5. Compare the effectiveness of PRF vs Physical Therapy in treating chronic knee

Inclusion Criteria:

- Age greater than 18

- Radiologic evidence of Kellgren-Lawrence knee arthritis between levels 1-3

- Satisfy the American College of Rheumatology criteria for knee osteoarthritis.

Exclusion Criteria:

- Failure to satisfy inclusion criteria

- Existence of general contraindications against percutaneous knee intervention
including (e.g. infection, hemorrhagic diathesis, anticoagulated patients)

- Patients with pacemaker or stimulator implants

- Metallic hardware located in the treatment knee of choice

- High clinical suspicion for alternative diagnosis other than Knee Osteoarthritis

- VA defined vulnerable populations (e.g. adults with cognitive impairments, mentally
retarded, non-english speaking, severe psychiatric disorders, prisoners, terminally
ill patient, employees, homeless, pregnant).

- Any patient that would not be able to follow up at 1 and 3 months after intervention.

- Any patient unwilling to receive physical therapy
We found this trial at
Long Beach, California 90822
Principal Investigator: Ronald Takemoto, MD
Phone: 562-826-5554
Long Beach, CA
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