Pharmacogenetic Prediction of Metoprolol Effectiveness
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 30 - 80 |
| Updated: | 4/17/2018 |
| Start Date: | September 2014 |
| End Date: | March 2020 |
| Contact: | Andrew Monte, MD |
| Email: | andrew.monte@ucdenver.edu |
| Phone: | 720-848-6777 |
The investigators will prospectively follow a population of patients with uncontrolled high
blood pressure beginning metoprolol succinate therapy to determine the drug effect in an
observational clinical trial. The investigators will determine each individual's genotype for
both CYP2D6 and Adrenoceptor Beta 1 (ADRB1). Metabolomic markers will be identified to
determine if specific metabolites are associated with drug response. The investigators'
overall objective is to determine if genetics predicts metoprolol succinate response better
than clinical factors such as age, race, body mass index, dose, and medication co-ingestion.
blood pressure beginning metoprolol succinate therapy to determine the drug effect in an
observational clinical trial. The investigators will determine each individual's genotype for
both CYP2D6 and Adrenoceptor Beta 1 (ADRB1). Metabolomic markers will be identified to
determine if specific metabolites are associated with drug response. The investigators'
overall objective is to determine if genetics predicts metoprolol succinate response better
than clinical factors such as age, race, body mass index, dose, and medication co-ingestion.
Inclusion Criteria:
1. Subjects between age >30 years and < 80 years
2. Subjects have diagnosis of uncontrolled essential hypertension.
Exclusion Criteria:
1. end stage liver disease,
2. end stage renal disease,
3. pregnant females,
4. American Society of Anesthesiologists (ASA) classification of >3,
5. wards of the state, prisoners,
6. decisionally challenged,
7. HR<60 bpm,
8. AV block>240 msec,
9. active reactive airway disease,
10. illicit drug abuse in the preceding 30 days,
11. hypersensitivity to metoprolol or its derivatives
12. severe peripheral arterial circulatory disorders.
Subjects will have a screening physical exam performed by Dr. Monte prior to enrollment in
the study.
We found this trial at
1
site
Aurora, Colorado 80045
Principal Investigator: Andrew Monte, MD
Phone: 303-724-7871
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