Trial of Linaclotide in Patients With Chronic Idiopathic Constipation

Inclusion Criteria:

- Patient has completed a colonoscopy if one is needed according to the AGA criteria,
with no clinically significant findings

- Patient has no clinically significant findings on a physical examination and clinical
laboratory tests

- Patient meets protocol criteria for CIC: reports < 3 bowel movements per week and
reports one or more of the following during ≥ 25% of BMs: straining, lumpy or hard
stools, sensation of incomplete evacuation

- Patient demonstrates continued chronic idiopathic constipation through Pretreatment
Period

- Patient is compliant with daily IVRS (interactive voice response system) calls

Exclusion Criteria:

- Patient has history of loose or watery stools

- Patient has symptoms of or been diagnosed with Irritable Bowel Syndrome (IBS)

- Patient has a structural abnormality of the gastrointestinal (GI) tract or a disease
or condition that can affect GI motility

- Patient has any protocol-excluded or clinically significant medical or surgical
history that could confound the study assessments