National Prevalence and Impact of Noninvasive Prenatal Testing

Information regarding the frequency of non-invasive testing (NIPT), the impact of screening
on the need for and frequency of invasive testing, and the indications for testing are
important for the clinicians in this country to not only understand the impact that this
testing has had but also to plan for allocation of personnel and resources in their prenatal
testing units, as well as many other more subtle changes including describing changes to
referring clinicians and patients and projecting financial impacts. Information on pregnant
women undergoing NIPT at one of the Obstetrix Medical Groups Outpatient Centers between
January 2012 and June 2014 will be retrospectively gathered and compared to a control group
of pregnant women in those same practices undergoing prenatal testing during the months of
January 2010-July 2010. An analysis of the impact of NIPT will be done.

Inclusion Criteria:

- Pregnant Women

- Presented to a participating Obstetrix Outpatient Center for an invasive prenatal
diagnostic testing for fetal karyotype (IDTFK) (i.e. amniocentesis or CVS).

- Invasive prenatal diagnostic testing for fetal karyotype (IDTFK) (i.e. amniocentesis
or CVS) performed between January 2012 and June 2014 (A control group enrolled between
January 2010 - July 2010)

Exclusion Criteria:

- Patient less than 18 years of age

- Patients not receiving a invasive prenatal diagnostic testing for fetal karyotype
(IDTFK)(i.e. amniocentesis or CVS) at a participating study center

- Testing NOT done within the window for inclusion (Jan 2012 - June 2014) or Control
Group window (January 2010 - July 2010)