Dual Energy CT Urography With Reduced Iodinated Contrast
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 5/16/2018 |
| Start Date: | September 2014 |
| End Date: | August 2017 |
Dual Energy CT Urography Using 50% Reduction in Iodinated Contrast: Feasibility, Image Quality, and Radiation Dose Reduction With Virtual Unenhanced Images.
The goal of this study is to validate that Dual Energy CT (DECT) urography when performed
with a 50% reduction in iodinated contrast dose results in a CT exam with equal or better
image quality and equal or better diagnostic capability compared to traditional Single Energy
CT (SECT) performed with a standard contrast dose.
with a 50% reduction in iodinated contrast dose results in a CT exam with equal or better
image quality and equal or better diagnostic capability compared to traditional Single Energy
CT (SECT) performed with a standard contrast dose.
The investigators hypothesize that DECT urography performed with a 50% iodine dose reduction
is equivalent to SECT urography performed with a full iodine dose for:
- Enhancement of the aorta, renal arteries, and renal veins
- Enhancement of the renal cortex
- Enhancement of the renal pelvis, ureters, and bladder
- Subjective evaluation of image quality
- Objective evaluation of image quality
In addition, the investigators hypothesize that DECT virtual non-contrast images using
material suppression from the same low iodine CT exam results in equivalent diagnostic
information compared to SECT true non-contrast images obtained in the same patient during the
same exam. If the true non-contrast images could be replaced by the virtual non-contrast
images without loss of information, there is potential for DECT to both significantly lower
radiation dose as well as significantly decreasing iodine dose.
The investigators designed this research protocol to prospectively test these hypotheses in a
population scanned with a 50% reduced iodine DECT urography protocol compared to a control
population scanned with a standard iodine dose clinical SECT urography protocol.
is equivalent to SECT urography performed with a full iodine dose for:
- Enhancement of the aorta, renal arteries, and renal veins
- Enhancement of the renal cortex
- Enhancement of the renal pelvis, ureters, and bladder
- Subjective evaluation of image quality
- Objective evaluation of image quality
In addition, the investigators hypothesize that DECT virtual non-contrast images using
material suppression from the same low iodine CT exam results in equivalent diagnostic
information compared to SECT true non-contrast images obtained in the same patient during the
same exam. If the true non-contrast images could be replaced by the virtual non-contrast
images without loss of information, there is potential for DECT to both significantly lower
radiation dose as well as significantly decreasing iodine dose.
The investigators designed this research protocol to prospectively test these hypotheses in a
population scanned with a 50% reduced iodine DECT urography protocol compared to a control
population scanned with a standard iodine dose clinical SECT urography protocol.
Inclusion Criteria:
- Age >50
- Outpatient scheduled to have a CT urography at the site
Exclusion Criteria:
- Severe allergy to iodine containing contrast
- Pregnancy (which is very unlikely for those over 50)
- Body mass index (BMI) over 35 kg/m2
- Inability to provide informed consent
- Inpatient
We found this trial at
1
site
1959 NE Pacific St
Seattle, Washington 98195
Seattle, Washington 98195
(206) 598-3300
Phone: 206-543-4127
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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