Investigating the Role of the Polyol Pathway in the Central Nervous System

Therapuetic Areas:Endocrinology
Age Range:18 - 55
Start Date:February 2015
End Date:June 30, 2020
Contact:Janice Hwang, MD

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Investigating the Role of Polyol Pathway in the Central Nervous System

Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure
intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of
hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess
cerebrospinal fluid levels of metabolites.

Inclusion Criteria:

- Type 2 DM with HbA1C treated with metformin, sulfonylurea, insulin, or combination OR
age-matched, non-diabetic obese (BMI > 30 kg/m^2) OR age-matched lean, healthy control
subjects (BMI < 25 kg/m^2)

- Age 18-55

- BMI 18-45 kg/m^2

Exclusion Criteria:

- Creatinine > 1.5 mg/dL

- Hgb < 10 mg/dL

- ALT > 2.5 x ULN

- Untreated thyroid disease

- Uncontrolled Hypertension

- Known Neurological Disorders

- Untreated Psychiatric Disorders

- Malignancy

- Bleeding Disorders

- Smoking

- Current or recent steroid use in last 3 months

- Illicit drug use

- Pregnancy, actively seeking pregnancy, or breastfeeding

- Inability to enter MRI/MRS
We found this trial at
New Haven, Connecticut 6520
(203) 432-4771
Phone: 203-785-6222
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New Haven, CT
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