Single Embryo TrAnsfeR of Euploid Embryo



Status:Active, not recruiting
Conditions:Other Indications, Women's Studies, Infertility
Therapuetic Areas:Other, Reproductive
Healthy:No
Age Range:25 - 40
Updated:3/2/2017
Start Date:September 2014
End Date:June 2017

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Prospective, Multi-center, Randomized Controlled Trial Comparing Pregnancy Outcomes Following Selection and Single Embryo Transfer (SET) Based on Preimplantation Genetic Screening (PGS) by Next Generation Sequencing (NGS) Versus Standard Morphological Assessment

The purpose of the current study is to evaluate the effect of preimplantation genetic
screening (PGS) by next generation sequencing (NGS) compared to standard morphological
assessment of embryos on pregnancy rates through a randomized controlled trial (RCT). All
embryos will be vitrified and a single embryo transfer (SET) will be performed with either
screened or unscreened embryos depending on randomization.


Inclusion Criteria:

- Patient undergoing IVF

- At least 2 blastocysts suitable for biopsy on day 5 or 6 of embryo development

Exclusion Criteria:

- History of more than two prior implantation failure following IVF

- History of more than one miscarriage of viable pregnancy

- One or both partners known to be carrier(s) of a chromosomal abnormality

- Known genetic carrier couple and/or one or both partners carrier of a known autosomal
dominant disorder

- Any other non-study related preimplantation genetic testing

- Use of donor oocytes

- Use of gestational carrier (surrogate or donor egg recipient).

- Severe oligospermia (<1,000,000 sperm/ml); Surgical Sperm Retrieval for reasons other
than post-vasectomy and CAVD

- Low ovarian reserve with (FSH) >10 IU/L on day 2-4 of a prior menstrual cycle and/or
(AMH) <7 pmol/L (or <1 ng/ml)

- Gender selection cycles

- Concurrent participation in another clinical trial
We found this trial at
28
sites
Webster, Texas 77598
1377
mi
from 91732
Webster, TX
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1919
mi
from 91732
Atlanta, GA
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Bloomfield Hills, Michigan 48304
1958
mi
from 91732
Bloomfield Hills, MI
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Bryn Mawr, Pennsylvania 19010
2367
mi
from 91732
Bryn Mawr, PA
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Dallas, Texas 75231
1223
mi
from 91732
Dallas, TX
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Eatontown, New Jersey 07724
2432
mi
from 91732
Eatontown, NJ
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Encino, California 91436
29
mi
from 91732
Encino, CA
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Frisco, Texas 75034
1218
mi
from 91732
Frisco, TX
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Highland Park, Illinois 60035
1724
mi
from 91732
Highland Park, IL
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Honolulu, Hawaii 96814
2573
mi
from 91732
Honolulu, HI
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Houston, Texas 77063
1349
mi
from 91732
Houston, TX
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Laguna Niguel, California 92677
41
mi
from 91732
Laguna Niguel, CA
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Lexington, Massachusetts 02421
2569
mi
from 91732
Lexington, MA
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Livingston, New Jersey 07039
2416
mi
from 91732
Livingston, NJ
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Livingston, New Jersey 07078
2415
mi
from 91732
Livingston, NJ
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808
mi
from 91732
LoneTree, CO
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Melbourne, Victoria
7949
mi
from 91732
Melbourne,
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Naperville, Illinois 60540
1702
mi
from 91732
Naperville, IL
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2345
mi
from 91732
Newark, DE
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Orlando, Florida 32804
2184
mi
from 91732
Orlando, FL
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Pasadena, California 91105
9
mi
from 91732
Pasadena, CA
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Pleasant Grove, Utah 84062
554
mi
from 91732
Pleasant Grove, UT
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1694
mi
from 91732
Plymouth, MI
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San Diego, California 92123
106
mi
from 91732
San Diego, CA
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338
mi
from 91732
San Ramon, CA
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Sandy, Utah 84092
562
mi
from 91732
Sandy, UT
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Seattle, Washington 98109
963
mi
from 91732
Seattle, WA
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Tempe, Arizona 85284
353
mi
from 91732
Tempe, AZ
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