A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration



Status:Terminated
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:3/16/2019
Start Date:October 6, 2014
End Date:January 23, 2018

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A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled
study evaluating the efficacy and safety of lampalizumab administered by intravitreal
injections in participants with geographic atrophy (GA) secondary to age-related macular
degeneration (AMD).


Inclusion Criteria:

- Participants aged greater than or equal to (>/=) 50 years

- Well demarcated area(s) of Geographic Atrophy (GA) secondary to Age-Related Macular
Degeneration (AMD) with no evidence of prior or active choroidal neovascularization
(CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria (Study Eye):

- History of vitrectomy surgery, submacular surgery, or other surgical intervention for
AMD

- Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein
occlusion, and proliferative diabetic retinopathy

- Previous intravitreal drug delivery (e.g., intravitreal corticosteroid injection,
anti-angiogenic drugs, anti-complement agents, or device implantation)

Ocular Exclusion Criteria (Both Eyes):

- GA in either eye due to causes other than AMD

- Previous treatment with eculizumab, lampalizumab, and/or fenretinide
We found this trial at
68
sites
2351 Erwin Road
Durham, North Carolina 27710
2199
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Durham, NC
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
1919
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Atlanta, GA
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4202 E Fowler Ave
Tampa, Florida 33620
(813) 974-2011
University of South Florida The University of South Florida is a high-impact, global research university...
2135
mi
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Tampa, FL
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5441 Health Center Drive
Abilene, Texas 79606
1057
mi
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Abilene, TX
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Ann Arbor, Michigan 48105
1931
mi
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Ann Arbor, MI
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21 Medical Park Drive
Asheville, North Carolina 28803
2004
mi
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Asheville, NC
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616
mi
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Ashland, OR
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Aurora, Colorado 80045
820
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Aurora, CO
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Baltimore, Maryland 21209
2298
mi
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Baltimore, MD
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Baltimore, Maryland
2301
mi
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Baltimore, MD
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Bellevue, Washington 98004
961
mi
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Bellevue, WA
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243 Charles Street
Boston, Massachusetts 02114
2577
mi
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Boston, MA
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1832 Avenida Córdoba
Capital Federal, C1120AAN
6112
mi
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Capital Federal,
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735 Johnnie Dodds Boulevard
Charleston, South Carolina 29464
2187
mi
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Charleston, SC
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6035 Fairview Road
Charlotte, North Carolina 28210
2102
mi
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Charlotte, NC
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22903
2207
mi
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Charlottesville, VA
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1606 Gunbarrel Road
Chattanooga, Tennessee 37421
1862
mi
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Chattanooga, TN
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8 Ranoldo Terrace
Cherry Hill, New Jersey 08034
2384
mi
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Cherry Hill, NJ
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1815 Clarkson Road
Chesterfield, Missouri 63017
1553
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Chesterfield, MO
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Chevy Chase, Maryland 20815
2278
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Chevy Chase, MD
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Cincinnati, Ohio 45242
1880
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Cincinnati, OH
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2770 North Union Boulevard
Colorado Springs, Colorado 80909
804
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Colorado Springs, CO
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1960
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Columbus, OH
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Dallas, Texas 75231
1226
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Dallas, TX
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Detroit, Michigan 48201
1966
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Detroit, MI
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7760 France Avenue South
Edina, Minnesota 55435
1504
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Edina, MN
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Florence, South Carolina 29501
2174
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Florence, SC
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Fort Lauderdale, Florida 33334
2314
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Fort Lauderdale, FL
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Fort Myers, Florida 33907
2205
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Fort Myers, FL
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Fullerton, California 92835
12
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Fullerton, CA
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1432 Kimbrough Road
Germantown, Tennessee 38138
1601
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Germantown, TN
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Golden, Colorado 80401
807
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Golden, CO
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Hamden, Connecticut 06518
2487
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Hamden, CT
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Houston, Texas 77030
1357
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Houston, TX
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La Jolla, California 92093
99
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La Jolla, CA
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9551 U.S. 78
Ladson, South Carolina 29456
2172
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Ladson, SC
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Los Angeles, California
13
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Los Angeles, CA
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2485 Hospital Drive
Mountain View, California 94040
322
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Mountain View, CA
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3880 Tamiami Trail North
Naples, Florida 34103
2218
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Naples, FL
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New York, New York 10021
2435
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New York, NY
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460 Park Avenue
New York, New York 10022
2434
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New York, NY
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1500 Tilton Road
Northfield, New Jersey 08225
2411
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Northfield, NJ
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Omaha, Nebraska 68105
1298
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Omaha, NE
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Paducah, Kentucky 42001
1659
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Paducah, KY
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2452 Watson Court
Palo Alto, California 94303
327
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Palo Alto, CA
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Philadelphia, Pennsylvania 19107
2375
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Philadelphia, PA
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Phoenix, Arizona 85020
343
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Phoenix, AZ
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420 East North Avenue
Pittsburgh, Pennsylvania 15212
2118
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Pittsburgh, PA
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Portland, Oregon 97210
827
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Portland, OR
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3303 Southwest Bond Avenue
Portland, Oregon 97239
826
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Portland, OR
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Poway, California 92064
95
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Poway, CA
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Rapid City, South Dakota 57701
1049
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Rapid City, SD
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Reno, Nevada 89502
385
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Reno, NV
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160 Sawgrass Drive
Rochester, New York 14620
2245
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Rochester, NY
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Sacramento, California 95817
363
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Sacramento, CA
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Sacramento, California 95819
366
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Sacramento, CA
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4344 Central Avenue North
Saint Petersburg, Florida 33711
2127
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Saint Petersburg, FL
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Santa Barbara, California 93103
98
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Santa Barbara, CA
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2439 Care Drive
Tallahassee, Florida 32308
1979
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Tallahassee, FL
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628 Cedar Lane
Teaneck, New Jersey 07666
2430
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Teaneck, NJ
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Temple, Texas 76508
1211
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Temple, TX
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The Woodlands, Texas 77384
1340
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The Woodlands, TX
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Towson, Maryland 21204
2301
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Tucson, Arizona 85724
427
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Walnut Creek, California 94598
348
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Walnut Creek, CA
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Waterford, Connecticut 06385
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Waterford, CT
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West Des Moines, Iowa 50266
1415
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West Des Moines, IA
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Wichita, Kansas 67214
1183
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Wichita, KS
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