PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
| Status: | Completed |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/11/2017 |
| Start Date: | September 2014 |
| End Date: | April 2016 |
Randomized, Double-Blind, Study Comparing Oral Acetaminophen Plus Intravenous (IV) Placebo to Oral Placebo Plus IV Acetaminophen Given Perioperatively for Controlling Pain in the 24hr Post-op Period After Total Hip or Knee Joint Replacement
The purpose of the study is to evaluate post-op pain requirements in patients undergoing hip
or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV
acetaminophen
or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV
acetaminophen
Subjects will be randomized to receive perioperative dosing of either:
1. Oral acetaminophen (Tylenol) 1000mg with IV Placebo (100ml Normal Saline), OR,
2. IV acetaminophen (Ofirmev) 1000mg/100ml with Oral Placebo (oral capsules).
Subject pain levels and post-operative opioid use will be tracked for up to 24 hours after
surgery.
1. Oral acetaminophen (Tylenol) 1000mg with IV Placebo (100ml Normal Saline), OR,
2. IV acetaminophen (Ofirmev) 1000mg/100ml with Oral Placebo (oral capsules).
Subject pain levels and post-operative opioid use will be tracked for up to 24 hours after
surgery.
Inclusion Criteria:
- 18 years of age and older
- Able to provide written consent
- Able to read and write in English
- Weighing over 50 kg
- Will undergo total hip or total knee joint replacement
Exclusion Criteria:
- Non-verbal patients
- Unable to use numeric pain scale
- Allergic to the test article
- Documented hepatic impairment or failure
- Current illicit drug use
- Requires traumatic or emergent surgery
- Pregnant women
- Women who are breastfeeding
- Prisoners
- Cognitively impaired requiring Legally Authorized Representative (LAR) or Power of
Attorney (POA)
- Unable to swallow oral capsules
We found this trial at
1
site
3535 Southern Blvd
Kettering, Ohio 45429
Kettering, Ohio 45429
(937) 298-4331
Principal Investigator: Skip Hickman, RPh
Phone: 937-395-8390
Kettering Medical Center Our flagship hospital, Kettering Medical Center, stands proudly in Kettering, Ohio. From...
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