Topiramate-Phentermine Combinations for Cocaine Dependence
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 6/27/2018 |
| Start Date: | September 2014 |
| End Date: | June 2019 |
| Contact: | Craig R Rush, Ph.D. |
| Email: | crush2@email.uky.edu |
| Phone: | 859-257-5388 |
This study will determine the influence of topiramate (Topamax®) and phentermine (Adipex®),
alone and in combination, on the reinforcing, subjective and physiological effects of
cocaine.
alone and in combination, on the reinforcing, subjective and physiological effects of
cocaine.
Inclusion Criteria:
- Recent cocaine use by the intranasal or intravenous route
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular
functioning, chronic obstructive pulmonary disease, history of seizure or current or
past histories of serious psychiatric disorder that in the opinion of the study
physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to cocaine, topiramate or phentermine
We found this trial at
1
site
740 South Limestone Street
Lexington, Kentucky 40536
Lexington, Kentucky 40536
Principal Investigator: Craig R Rush, Ph.D.
Phone: 859-257-5388
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