Growth of Airways and Lung Tissues in Premature and Healthy Infants
| Status: | Completed |
|---|---|
| Conditions: | Asthma, Bronchitis, Women's Studies |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/19/2019 |
| Start Date: | September 2006 |
| End Date: | January 2019 |
Growth of Airways and Lung Parenchyma
The purpose of this study is to evaluate the growth of the lung and how easily gas can be
taken up by the lung in healthy infants born at full term without any breathing problems and
infants born prematurely.
taken up by the lung in healthy infants born at full term without any breathing problems and
infants born prematurely.
SPECIFIC AIM # 1: Determine the relationship between parenchymal tissue and alveolar volume
with normal lung growth early in life We hypothesize that during the first two years of life
that parenchymal surface area and alveolar volume increase with somatic growth; however, the
ratio of surface area to volume remains constant, while ventilation within the lung becomes
more homogenous.
SPECIFIC AIM # 2: Determine the pulmonary sequelae of premature birth and assess the
effectiveness of early treatment strategies upon the pulmonary sequelae.
We hypothesize that premature birth impedes growth and development of the lung parenchyma and
the airways at a corrected-age of 1-year. In addition, initiating continuous positive airway
pressure (CPAP) and a permissive ventilatory strategy in very premature infants at birth will
improve lung growth and lung function compared to treatment with early surfactant and
conventional ventilation.
with normal lung growth early in life We hypothesize that during the first two years of life
that parenchymal surface area and alveolar volume increase with somatic growth; however, the
ratio of surface area to volume remains constant, while ventilation within the lung becomes
more homogenous.
SPECIFIC AIM # 2: Determine the pulmonary sequelae of premature birth and assess the
effectiveness of early treatment strategies upon the pulmonary sequelae.
We hypothesize that premature birth impedes growth and development of the lung parenchyma and
the airways at a corrected-age of 1-year. In addition, initiating continuous positive airway
pressure (CPAP) and a permissive ventilatory strategy in very premature infants at birth will
improve lung growth and lung function compared to treatment with early surfactant and
conventional ventilation.
Inclusion Criteria:
- Group 1
- full term greater than 37 weeks
- Group 3
- infants born premature between 23-35 weeks of age to be tested between the ages of two
to twenty four months corrected.
Exclusion Criteria:
- heart disease
- severe developmental delays
We found this trial at
1
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Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
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