A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)



Status:Completed
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/30/2019
Start Date:September 30, 2014
End Date:April 19, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A PHASE 3, RANDOMIZED, DOUBLE-BLIND STUDY OF PF-05280586 VERSUS RITUXIMAB FOR THE FIRST-LINE TREATMENT OF PATIENTS WITH CD20-POSITIVE, LOW TUMOR BURDEN, FOLLICULAR LYMPHOMA

This study will compare the safety and effectiveness of PF-05280586 versus rituximab-EU in
patients with CD20-positive, low tumor burden follicular lymphoma. The primary hypothesis to
be tested in this study is that the effectiveness of PF-05280586, as measured by the Overall
Response Rate, is similar to that of rituximab-EU.


Inclusion Criteria:

- Confirmed diagnosis of low tumor burden, CD20-positive follicular lymphoma

- Ann Arbor Stage II, III, or IV

Exclusion Criteria:

- Not a candidate for treatment with rituximab as a single-agent

- Evidence of transformation to a high grade or diffuse large B-cell lymphoma

- Any previous systemic therapy for B-cell NHL, including chemotherapy, immunotherapy,
or steroids

- Any prior treatment with rituximab

- Active, uncontrolled infection
We found this trial at
91
sites
Cancer Center of Kansas
818 N. Emporia, #403
Wichita, Kansas 67214
(316) 262-4467
Cancer Center of Kansas The physicians of Cancer Center are hematologists and oncologists. The staff...
1182
mi
from 91732
Wichita, KS
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Pacific Cancer Medical Center
Anaheim, California 92801
16
mi
from 91732
Anaheim, CA
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The Oncology Institute of Hope and Innovation
1801 West Romneya Drive
Anaheim, California 92801
15
mi
from 91732
Anaheim, CA
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Rocky Mountain Cancer Centers
Aurora, Colorado 80012
824
mi
from 91732
Aurora, CO
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PET/CT facility Seton Imaging Center
4504 Seminole Avenue
Baltimore, Maryland 21229
2297
mi
from 91732
Baltimore, MD
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Saint Agnes Hospital
Baltimore, Maryland 21229
2301
mi
from 91732
Baltimore, MD
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Rcca Md, Llc
Bethesda, Maryland 20817
2277
mi
from 91732
Bethesda, MD
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Rocky Mountain Cancer Centers, Site #191
Boulder, Colorado 80303
815
mi
from 91732
Boulder, CO
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Cancer Center of Kansas
Chanute, Kansas 66720
1283
mi
from 91732
Chanute, KS
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Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc.
Corona, California 92879
30
mi
from 91732
Corona, CA
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Northwestern Medicine West Region
DeKalb, Illinois 60115
?
mi
from 91732
DeKalb, IL
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Rocky Mountain Cancer Centers
Denver, Colorado 80218
818
mi
from 91732
Denver, CO
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Cancer Center of Kansas
Dodge City, Kansas 67801
1036
mi
from 91732
Dodge City, KS
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The Oncology Institute of Hope and Innovation
Downey, California 90241
11
mi
from 91732
Downey, CA
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Cancer Center of Kansas
El Dorado, Kansas 67042
1208
mi
from 91732
El Dorado, KS
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Willamette Valley Cancer Institute/Research Ctr
Eugene, Oregon 97401
741
mi
from 91732
Eugene, OR
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San Antonio Military Medical Center
Fort Sam Houston, Texas 78234
1190
mi
from 91732
Fort Sam Houston, TX
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San Antonio Military Medical Center- Department of Radiology
Fort Sam Houston, Texas 78234
1190
mi
from 91732
Fort Sam Houston, TX
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San Antonio Military Medical Center- Department of Pharmacy
3551 Roger Brooke Drive
Fort Sam Houston, Texas 78234
1192
mi
from 91732
Fort Sam Houston, TX
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Investigational Products Center (IPC)
Fort Worth, Texas 76177
1195
mi
from 91732
Fort Worth, TX
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Investigational Products Center (IPC)
Fort Worth, Texas 76177
1195
mi
from 91732
Fort Worth, TX
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Investigational Products Center (I PC)
Fort Worth, Texas 76177
1195
mi
from 91732
Fort Worth, TX
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Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc.
Fountain Valley, California 92708
25
mi
from 91732
Fountain Valley, CA
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Cancer Center,Northwestern Medicine, West Region
Geneva, Illinois 60134
1695
mi
from 91732
Geneva, IL
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Global Cancer Research Institute (GCRI), Inc.
Gilroy, California 95020
284
mi
from 91732
Gilroy, CA
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Saint Louise Regional Hospital Radiology Department (Radiology Only)
Gilroy, California 95020
284
mi
from 91732
Gilroy, CA
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South Valley Imaging Center (Imaging Only)
Gilroy, California 95020
284
mi
from 91732
Gilroy, CA
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Los Angeles Hematology Oncology Medical Group
Glendale, California 91206
14
mi
from 91732
Glendale, CA
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Los Angeles Hematology Oncology Medical Group
Glendale, California 91206
14
mi
from 91732
Glendale, CA
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The Oncology Institute of Hope and Innovation
1510 South Central Avenue
Glendale, California 91204
14
mi
from 91732
Glendale, CA
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Saint Francis Medical Center, Saint Francis Cancer Treatment Center
Grand Island, Nebraska 68803
1143
mi
from 91732
Grand Island, NE
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Saint Francis Medical Center
Grand Island, Nebraska 68803
1171
mi
from 91732
Grand Island, NE
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Vidant Medical Center
Greenville, North Carolina 27834
2290
mi
from 91732
Greenville, NC
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Vidant Medical Center Pharmacy
Greenville, North Carolina 27834
2290
mi
from 91732
Greenville, NC
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Brody School of Medicine at East Carolina University
Greenville, North Carolina 27834
2290
mi
from 91732
Greenville, NC
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Saint Francis Medical Center, Saint Francis Cancer Treatment Center
Hastings, Nebraska 68901
1165
mi
from 91732
Hastings, NE
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Comprehensive Cancer Centers of Nevada
Henderson, Nevada
218
mi
from 91732
Henderson, NV
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Comprehensive Cancer Centers of Nevada
Henderson, Nevada
218
mi
from 91732
Henderson, NV
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Millennium Oncology
Houston, Texas 77090
1348
mi
from 91732
Houston, TX
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Cancer Center of Kansas
Independence, Kansas 67301
1268
mi
from 91732
Independence, KS
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US Oncology Investigational Products Center (IPC)
Irving, Texas 75063
1211
mi
from 91732
Irving, TX
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The University of Kansas Cancer Center
Kansas City, Missouri 64154
1340
mi
from 91732
Kansas City, MO
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The University of Kansas Cancer Center
Kansas City, Missouri 64154
1340
mi
from 91732
Kansas City, MO
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Cancer Center of Kansas
Kingman, Kansas 67068
1138
mi
from 91732
Kingman, KS
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Millennium Oncology
22710 Professional Drive
Kingwood, Texas 77339
1358
mi
from 91732
Kingwood, TX
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University of Tennessee Medical Center
Knoxville, Tennessee 37920
1925
mi
from 91732
Knoxville, TN
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Rocky Mountain Cancer Centers (RMCC) - Lakewood -St Anthony
Lakewood, Colorado 80228
810
mi
from 91732
Lakewood, CO
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Rocky Mountain Cancer Center-Lakewood (Laboratory)
Lakewood, Colorado 80228
808
mi
from 91732
Lakewood, CO
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Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
206
mi
from 91732
Las Vegas, NV
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Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
206
mi
from 91732
Las Vegas, NV
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Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
206
mi
from 91732
Las Vegas, NV
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The University of Kansas Cancer Center
Lee's Summit, Missouri 64064
1351
mi
from 91732
Lee's Summit, MO
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Cancer Center of Kansas
Liberal, Kansas 67905
980
mi
from 91732
Liberal, KS
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Krankenhaus der Barmherzigen Schwestern Linz
Linz,
?
mi
from 91732
Linz,
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Rocky Mountain Cancer Centers
Lone Tree, Colorado 80124
816
mi
from 91732
Lone Tree, CO
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Oncology Institute of Hope and Innovation
Long Beach, California
23
mi
from 91732
Long Beach, CA
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Texas Oncology-Longview Cancer Center
Longview, Texas 75601
1346
mi
from 91732
Longview, TX
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Los Angeles Hematology/Oncology Medical Group
Los Angeles, California 90017
14
mi
from 91732
Los Angeles, CA
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Oncology Institute of Hope and Innovation
Lynwood, California 90262
15
mi
from 91732
Lynwood, CA
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Toledo Clinic Cancer Center - Maumee
Maumee, Ohio 43537
1931
mi
from 91732
Maumee, OH
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Cancer Center of Kansas
McPherson, Kansas 67460
1169
mi
from 91732
McPherson, KS
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The Oncology Institute of Hope and Innovation
Montebello, California 90640
6
mi
from 91732
Montebello, CA
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Cancer Center of Kansas
Newton, Kansas 67114
1183
mi
from 91732
Newton, KS
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The University of Kansas Cancer Center
Overland Park, Kansas 66210
1333
mi
from 91732
Overland Park, KS
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Comprehensive Cancer Center At Desert Regional Medical Center
Palm Springs, California 92262
85
mi
from 91732
Palm Springs, CA
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Cancer Center of Kansas
Parsons, Kansas 67357
1293
mi
from 91732
Parsons, KS
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Rocky Mountain Cancer Center Pueblo
3676 Parker Boulevard
Pueblo, Colorado 81008
799
mi
from 91732
Pueblo, CO
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Torrance Health Association Dba Torrance Memorial Physician Network/Cancer Care Associates
Redondo Beach, California 90277
26
mi
from 91732
Redondo Beach, CA
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Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc.
Riverside, California 92501
37
mi
from 91732
Riverside, CA
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Cancer Center of Kansas
Salina, Kansas 67401
1177
mi
from 91732
Salina, KS
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Global Cancer Research Institute
San Jose, California 95124
310
mi
from 91732
San Jose, CA
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OConnor Hospital
San Jose, California 95128
314
mi
from 91732
San Jose, CA
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PET Imaging of San Jose (Imaging Only)
San Jose, California 95128
374
mi
from 91732
San Jose, CA
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The Oncology Institute of Hope and Innovation
Santa Ana, California 92705
78
mi
from 91732
Santa Ana, CA
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Millennium Oncology
Shenandoah, Texas 77384
1344
mi
from 91732
Shenandoah, TX
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Holy Cross Hospital Resource Center
Silver Spring, Maryland 20902
2280
mi
from 91732
Silver Spring, MD
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Holy Cross Hospital
Silver Spring, Maryland 20910
2280
mi
from 91732
Silver Spring, MD
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Holy Cross Hospital, Hospital Pharmacy
1500 Forest Glen Road
Silver Spring, Maryland 20910
2280
mi
from 91732
Silver Spring, MD
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Millennium Oncology
9319 Pinecroft Drive
The Woodlands, Texas 77380
1344
mi
from 91732
The Woodlands, TX
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John D. Archbold Memorial Hospital
Thomasville, Georgia 31799
1987
mi
from 91732
Thomasville, GA
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Lewis Hall Singletary Oncology Center at John D. Archbold Memorial Hospital
Thomasville, Georgia 31792
1987
mi
from 91732
Thomasville, GA
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Toledo Clinic Cancer Center-Toledo
Toledo, Ohio 43623
1937
mi
from 91732
Toledo, OH
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Toledo Clinic Inc.
Toledo, Ohio 43623
1932
mi
from 91732
Toledo, OH
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Torrance Memorial Medical Center
Torrance, California 90505
26
mi
from 91732
Torrance, CA
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Texas Oncology-Tyler
Tyler, Texas 75702
1315
mi
from 91732
Tyler, TX
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Cancer Center of Kansas
Wellington, Kansas 67152
1176
mi
from 91732
Wellington, KS
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Maryland Oncology Hematology, P.A.
Wheaton, Maryland 20902
2280
mi
from 91732
Wheaton, MD
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The Oncology Institute of Hope and Innovation
Whittier, California 90606
7
mi
from 91732
Whittier, CA
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Innovative Clinical Research Institute (ICRI)
Whittier, California 90603
8
mi
from 91732
Whittier, CA
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Cancer Center of Kansas
Winfield, Kansas 67156
1197
mi
from 91732
Winfield, KS
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Yakima Valley Memorial Hospital North Star Lodge Cancer Center
Yakima, Washington 98902
874
mi
from 91732
Yakima, WA
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