Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2014 |
| End Date: | July 2017 |
| Contact: | Evan L Brittain, MD |
| Phone: | 615-875-5500 |
The purpose of the study is to measure RV ejection fraction (RVEF), pulmonary flow, and
pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with
pulmonary arterial hypertension (PAH) who are known to be vasodilator-responsive based on
invasive catheterization as well as healthy subjects. Measurements will also be made after
high flow oxygen alone to test the relative vasodilatory effect of oxygen and NO. The
investigators hypothesize is that inhaled nitric oxide during cardiac MRI can be used to
measure dynamic changes in RV-pulmonary vascular function in patients with
vasodilator-responsive PAH.
pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with
pulmonary arterial hypertension (PAH) who are known to be vasodilator-responsive based on
invasive catheterization as well as healthy subjects. Measurements will also be made after
high flow oxygen alone to test the relative vasodilatory effect of oxygen and NO. The
investigators hypothesize is that inhaled nitric oxide during cardiac MRI can be used to
measure dynamic changes in RV-pulmonary vascular function in patients with
vasodilator-responsive PAH.
Inclusion Criteria:
- Patients age 18 or older of the Vanderbilt Center for Pulmonary Vascular Disease.
Vasodilator-responsive patients will be identified based on prior response to inhaled
nitric oxide during invasive right heart catheterization
- Healthy subjects age 18 or older not known to have cardiopulmonary disease
Exclusion Criteria:
- Standard conventional contraindications for cardiac magnetic resonance (CMR) imaging
- Allergy or contraindication to Magnevist (gadopentetate dimeglumine) contrast
- Concurrent intravenous epoprostenol infusion in whom performance of CMR is cumbersome
- Pregnant women
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Principal Investigator: Evan L Brittain, MD
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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