Safety Study of SGN-CD70A in Cancer Patients



Status:Completed
Conditions:Cancer, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2018
Start Date:August 2014
End Date:February 15, 2017

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A Phase 1 Trial of SGN-CD70A in Patients With CD70-Positive Malignancies

This study will examine the safety profile of SGN-CD70A. The study will test increasing doses
of SGN-CD70A given every 3 weeks (or an alternate dosing schedule up to every 6 weeks) to
small groups of patients. The goal is to find the highest dose of SGN-CD70A that can be given
to patients without causing unacceptable side effects. The pharmacokinetics and antitumor
activity of SGN-CD70A will also be evaluated.


Inclusion Criteria:

- Metastatic renal cell carcinoma, mantle cell lymphoma, or diffuse large B-cell
lymphoma including Grade 3b follicular lymphoma

- Relapsed, refractory, or progressive disease following at least 2 prior systemic
therapies

- Confirmed positive CD70 expression on tumor tissue

- Eastern Cooperative Oncology Group performance status 0 or 1

- Adequate baseline hematologic, pulmonary, renal, and hepatic function

- Measurable disease

Exclusion Criteria:

- Prior treatment with anti-CD70 directed therapy unless CD70 expression is confirmed on
tumor tissue obtained after the treatment

- Patients <100 days since prior allogeneic stem cell transplant

- Less than 4 weeks since prior treatment; or 2 weeks if patient experienced disease
progression on the prior treatment
We found this trial at
17
sites
601 Elmwood Avenue
Rochester, New York 14642
(585) 275-5830
Principal Investigator: Paul Barr, MD
Phone: 585-275-4911
James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
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Rochester, NY
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Andres Forero-Torres
Phone: 205-975-0960
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: John Sarantopoulos, MD
Phone: 210-450-5962
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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San Antonio, TX
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: David Smith, MD
Phone: 734-647-9437
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Ann Arbor, MI
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Austin, Texas 78705
Principal Investigator: Jason Melear, MD
Phone: 281-863-4697
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Austin, TX
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Chapel Hill, North Carolina 27599
Principal Investigator: Steven Park, MD
Phone: 919-843-7046
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Chapel Hill, NC
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Charleston, South Carolina 29425
Principal Investigator: Valeriy Sedov, MD
Phone: 843-792-1463
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Charleston, SC
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Cincinnati, Ohio 45267
Principal Investigator: John Morris, MD
Phone: 513-584-8500
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Cincinnati, OH
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Cleveland, Ohio 44106
Principal Investigator: Paolo Caimi, MD
Phone: 216-844-8573
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Cleveland, OH
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Detroit, Michigan
Principal Investigator: Elisabeth Heath, MD
Phone: 313-576-8495
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Detroit, MI
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1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Principal Investigator: Sumanta Kumar Pal, MD
Phone: 626-256-4673
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duarte, CA
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Houston, Texas 77030
Principal Investigator: Swaminathan Iyer, MD
Phone: 713-441-9984
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Houston, TX
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9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Principal Investigator: Nicholas Vogelzang, MD
Phone: 281-863-4697
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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2160 S. First Ave.
Maywood, Illinois 60153
888-584-7888
Principal Investigator: Scott Smith, MD
Phone: 708-327-3228
Cardinal Bernardin Cancer Center at Loyola University Medical Center The Cardinal Bernardin Cancer Center is...
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Maywood, IL
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Philadelphia, Pennsylvania 19104
Principal Investigator: Jakub Svoboda, MD
Phone: 215-662-2062
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Seattle, Washington 98109
Principal Investigator: John Thompson, MD
Phone: 206-288-6448
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Seattle, WA
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Vancouver, Washington 98684
Principal Investigator: Kathryn Kolibaba, MD
Phone: 281-863-4697
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